IRIT@CRCT
Equipe “MICHEL LAUDET”

IRIT@CRCT :

laboratoire de cancérologie numérique “Michel Laudet”

Le Centre de Recherches en Cancérologie de Toulouse (CRCT) et l’Institut de Recherche en Informatique de Toulouse (IRIT), opère un rapprochement inédit en créant un laboratoire intégré dans les locaux du CRCT. Fruit d’une longue coopération, les chercheurs du CRCT et de l’IRIT ont souhaité se rapprocher afin de pouvoir travailler en synergie au cœur même de l’Oncopole.

Aujourd’hui il est impossible de penser recherche en santé sans penser numérique tant le volume de données à traiter est devenu important. En apportant aux chercheurs du CRCT et de l’IUCT-O des compétences en intelligence artificielle, en mathématique, en simulation, en modélisation logique des systèmes et en vie artificielle, l’IRIT apporte un véritable coup d’accélérateur à la recherche du CRCT et permettra à terme de proposer rapidement des solutions innovantes pour une meilleure prise en charge aux patients atteints de cancer.

Cette collaboration sciences de la vie, sciences de l’informatique, intégrée dans un centre de recherche contre le cancer est une première en France. Ce laboratoire est un exemple réussi de la convergence des sciences de l’informatique vers les sciences de la santé au bénéfice de la recherche en cancérologie et des patients. La localisation sur un même site permet aux chercheurs du CRCT de mieux appréhender les outils de l’Informatique et de l’IA et aux chercheurs de l’IRIT de mieux comprendre les questions essentielles de la cancérologie. Ce laboratoire voit son activité débuter sur une croissance rapide et met en place de nombreux projets ambitieux dans le cadre de la lutte contre le cancer.

C’est dans ce cadre qu’Ibrahim Didi, co-encadré par le Dr Sarah Bertoli (CHU/CRCT) et David Simoncini (IRIT), s’est vu remettre le 02 décembre 2021 un prix de meilleur stage de recherche de l’Ecole Polytechnique pour son travail autour de l’utilisation de techniques d’IA pour la prédiction du pronostic et l’aide à la décision de traitement de la leucémie aiguë myéloïde. Ce travail a été présenté sous forme de poster au congrès de l’American Society of Hematology (2021) et sous forme de communication orale au congrès de la société française d’hématologie (2022).

Le laboratoire Michel Laudet en chiffre

  • 10 chercheurs de l’IRIT – 12 chercheurs du CRCT et de l’IUCT
  • 2 Thèses et 3 post-doctorant
  • 5 stagiaires en moyenne issus notamment des grandes écoles (Polytechnique, INSA Toulouse et École Centrale Paris, École des Mines)
  • Une dizaine de projets en cours ou émergents

NOS PROJETS
DE RECHERCHE

PRODUCTIONS SCIENTIFIQUES

PUBLICATIONS 2022
PUBLICATIONS 2021
Alliot, Jean-Marc, Marta Cialdea Mayer, Robert Demolombe, Martín Diéguez, and Luis Fariñas del Cerro. “A Framework for Modelling Molecular Interaction Maps.” FLAP 8, no. 7 (2021): 1917–52. https://collegepublications.co.uk/ifcolog/?00049.
PUBLICATIONS 2020
PUBLICATIONS 2019
Delaunay, Myriam, Grégoire Prévot, Samia Collot, Laurent Guilleminault, Alain Didier, and Julien Mazières. “Management of Pulmonary Toxicity Associated with Immune Checkpoint Inhibitors.” European Respiratory Review: An Official Journal of the European Respiratory Society 28, no. 154 (December 31, 2019). https://doi.org/10.1183/16000617.0012-2019.
Ploussard, Guillaume, Jean-Baptiste Beauval, Marine Lesourd, Christophe Almeras, Jacques Assoun, Richard Aziza, Jean-Romain Gautier, et al. “Impact of MRI and Targeted Biopsies on Eligibility and Disease Reclassification in MRI-Positive Candidates for Active Surveillance on Systematic Biopsies.” Urology, December 30, 2019. https://doi.org/10.1016/j.urology.2019.10.039.
Grondin, Anthony, Eloïse Baudou, Marlène Pasquet, Sonia Pelluau, Karim Jamal-Bey, Cécile Bermot, Frederic Villega, and Emmanuel Cheuret. “Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report.” Neuropediatrics, December 30, 2019. https://doi.org/10.1055/s-0039-3402011.
Siegfried, Aurore, Julien Masliah-Planchon, Franck-Emmanuel Roux, Delphine Larrieu-Ciron, Gaelle Pierron, Yvan Nicaise, Marion Gambart, et al. “Brain Tumor with an ATXN1-NUTM1 Fusion Gene Expands the Histologic Spectrum of NUTM1-Rearranged Neoplasia.” Acta Neuropathologica Communications 7, no. 1 (December 30, 2019): 220. https://doi.org/10.1186/s40478-019-0870-8.
Manrique, Alain, David Dudoignon, Stéphanie Brun, Catherine N’Ganoa, Emmanuelle Cassol, Damien Legallois, Yoan Lavie-Badie, Denis Agostini, and Olivier Lairez. “Quantification of Myocardial 99mTc-Labeled Bisphosphonate Uptake with Cadmium Zinc Telluride Camera in Patients with Transthyretin-Related Cardiac Amyloidosis.” EJNMMI Research 9, no. 1 (December 23, 2019): 117. https://doi.org/10.1186/s13550-019-0584-8.
Koffi, K. G., D. A. Silué, C. Laurent, K. Boidy, S. Koui, G. Compaci, Z. H. Adeba, et al. “AMAFRICA, a Patient-Navigator Program for Accompanying Lymphoma Patients during Chemotherapy in Ivory Coast: A Prospective Randomized Study.” BMC Cancer 19, no. 1 (December 23, 2019): 1247. https://doi.org/10.1186/s12885-019-6478-3.
Garnache-Ottou, Francine, Chrystelle Vidal, Sabeha Biichlé, Florian Renosi, Eve Poret, Maïder Pagadoy, Maxime Desmarets, et al. “How Should We Diagnose and Treat Blastic Plasmacytoid Dendritic Cell Neoplasm Patients?” Blood Advances 3, no. 24 (December 23, 2019): 4238–51. https://doi.org/10.1182/bloodadvances.2019000647.
Hofmann, Werner, Wei Bo Li, Werner Friedland, Brian W. Miller, Balázs Madas, Manuel Bardiès, and Imre Balásházy. “Internal Microdosimetry of Alpha-Emitting Radionuclides.” Radiation and Environmental Biophysics, December 21, 2019. https://doi.org/10.1007/s00411-019-00826-w.
Zamora, Audrey, Melinda Alves, Charlotte Chollet, Nicole Therville, Tiffany Fougeray, Florence Tatin, Camille Franchet, et al. “Paclitaxel Induces Lymphatic Endothelial Cells Autophagy to Promote Metastasis.” Cell Death & Disease 10, no. 12 (December 20, 2019): 956. https://doi.org/10.1038/s41419-019-2181-1.
Massé, Julie, Caroline Truntzer, Romain Boidot, Emmanuel Khalifa, Gaëlle Pérot, Valérie Velasco, Laétitia Mayeur, et al. “Solid-Type Adenoid Cystic Carcinoma of the Breast, a Distinct Molecular Entity Enriched in NOTCH and CREBBP Mutations.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, December 19, 2019. https://doi.org/10.1038/s41379-019-0425-3.
Franchet, Camille, and Jean-Sébastien Hoffmann. “When RAD52 Allows Mitosis to Accept Unscheduled DNA Synthesis.” Cancers 12, no. 1 (December 19, 2019). https://doi.org/10.3390/cancers12010026.
Meyrignac, Olivier, Élise Arcis, Marie-Charlotte Delchier, Fatima-Zohra Mokrane, Jean Darcourt, Hervé Rousseau, and Béatrice Bouhanick. “Impact of Cone Beam - CT on Adrenal Vein Sampling in Primary Aldosteronism.” European Journal of Radiology 124 (December 18, 2019): 108792. https://doi.org/10.1016/j.ejrad.2019.108792.
Appay, Romain, Caroline Dehais, Claude-Alain Maurage, Agusti Alentorn, Catherine Carpentier, Carole Colin, François Ducray, et al. “CDKN2A Homozygous Deletion Is a Strong Adverse Prognosis Factor in Diffuse Malignant IDH-Mutant Gliomas.” Neuro-Oncology 21, no. 12 (December 17, 2019): 1519–28. https://doi.org/10.1093/neuonc/noz124.
Mazerolle, P., T. Meresse, D. Gangloff, K. Kolsi, and A. Dupret-Bories. “Vascularized Lymph Node Transfer with Submental Free Flap.” European Annals of Otorhinolaryngology, Head and Neck Diseases, December 16, 2019. https://doi.org/10.1016/j.anorl.2019.11.004.
Ploussard, Guillaume, Cécile Manceau, Jean-Baptiste Beauval, Marine Lesourd, Christophe Almeras, Jean-Romain Gautier, Guillaume Loison, et al. “Decreased Accuracy of the Prostate Cancer EAU Risk Group Classification in the Era of Imaging-Guided Diagnostic Pathway: Proposal for a New Classification Based on MRI-Targeted Biopsies and Early Oncologic Outcomes after Surgery.” World Journal of Urology, December 14, 2019. https://doi.org/10.1007/s00345-019-03053-6.
Frigeni, Marco, Caroline Besson, Carlo Visco, Helene Fontaine, Maria Goldaniga, Marcella Visentini, Alessandro Pulsoni, et al. “Interferon-Free Compared to Interferon-Based Antiviral Regimens as First-Line Therapy for B-Cell Lymphoproliferative Disorders Associated with Hepatitis C Virus Infection.” Leukemia, December 13, 2019. https://doi.org/10.1038/s41375-019-0687-2.
Hantelys, Fransky, Anne-Claire Godet, Florian David, Florence Tatin, Edith Renaud-Gabardos, Françoise Pujol, Leila H. Diallo, et al. “Vasohibin1, a New Mouse Cardiomyocyte IRES Trans-Acting Factor That Regulates Translation during Early Hypoxia.” ELife 8 (December 9, 2019). https://doi.org/10.7554/eLife.50094.
Tang, Nicolas, Marta Bueno, Sylvain Meylan, Yann Perrot, Hoang N. Tran, Amélie Freneau, Morgane Dos Santos, et al. “Assessment of Radio-Induced Damage in Endothelial Cells Irradiated with 40 KVp, 220 KVp, and 4 MV X-Rays by Means of Micro and Nanodosimetric Calculations.” International Journal of Molecular Sciences 20, no. 24 (December 9, 2019). https://doi.org/10.3390/ijms20246204.
Péricart, Sarah, Charlotte Waysse, Aurore Siegfried, Stephanie Struski, Eric Delabesse, Camille Laurent, and Solène Evrard. “Subsequent Development of Histiocytic Sarcoma and Follicular Lymphoma: Cytogenetics and next-Generation Sequencing Analyses Provide Evidence for Transdifferentiation of Early Common Lymphoid Precursor-a Case Report and Review of Literature.” Virchows Archiv: An International Journal of Pathology, December 5, 2019. https://doi.org/10.1007/s00428-019-02691-w.
Sroussi, Marine, Reza Elaidi, Aude Fléchon, Marianne Lorcet, Delphine Borchiellini, Magalie P. Tardy, Gwenaelle Gravis, et al. “Neuroendocrine Carcinoma of the Urinary Bladder: A Large, Retrospective Study From the French Genito-Urinary Tumor Group.” Clinical Genitourinary Cancer, December 5, 2019. https://doi.org/10.1016/j.clgc.2019.11.014.
Lambo, Sander, Susanne N. Gröbner, Tobias Rausch, Sebastian M. Waszak, Christin Schmidt, Aparna Gorthi, July Carolina Romero, et al. “The Molecular Landscape of ETMR at Diagnosis and Relapse.” Nature, December 4, 2019. https://doi.org/10.1038/s41586-019-1815-x.
Compaci, Gisèle, Cécile Conte, Lucie Oberic, Loïc Ysebaert, Guy Laurent, and Fabien Despas. “Sustained Degradation of Quality of Life in a Subgroup of Lymphoma Survivors: A Two-Year Prospective Survey.” BMC Cancer 19, no. 1 (December 3, 2019): 1178. https://doi.org/10.1186/s12885-019-6337-2.
Dubucs, Charlotte, Céline Basset, Dominique D’Aure, Monique Courtade-Saïdi, and Solène M. Evrard. “A 4-Year Retrospective Analysis of Salivary Gland Cytopathology Using the Milan System for Reporting Salivary Gland Cytology and Ancillary Studies.” Cancers 11, no. 12 (December 1, 2019). https://doi.org/10.3390/cancers11121912.
Voron, Thibault, Caroline Gronnier, Arnaud Pasquer, Jeremie Thereaux, Johan Gagniere, Gil Lebreton, Bernard Meunier, et al. “Adenocarcinoma of the Oesophagogastric Junction Siewert II: An Oesophageal Cancer Better Cured with Total Gastrectomy.” European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 45, no. 12 (December 2019): 2473–81. https://doi.org/10.1016/j.ejso.2019.07.022.
Lesur, Anne, Florence Dalenc, and Marie Beguignot. “[Adjuvant endocrine therapy in premenopausal breast cancer: a initial dedicated counseling: can it be useful for better adherence?].” Bulletin Du Cancer 106, no. 12S1 (December 2019): S28–36. https://doi.org/10.1016/S0007-4551(20)30045-X.
Vergez, François, Laetitia Largeaud, Lucie Oberic, and Jean-Baptiste Rieu. “Do Not Jump to Hasty Conclusions: All Gamma Delta T-Cells Neoplasms Are Not Aggressive!” Blood Research 54, no. 4 (December 2019): 243. https://doi.org/10.5045/br.2019.54.4.243.
Guillaume, Maeva, Valerie Moal, Cyrielle Delabaudiere, Floraine Zuberbuhler, Marie-Angèle Robic, Adrien Lannes, Sophie Metivier, et al. “Direct Comparison of the Specialised Blood Fibrosis Tests FibroMeterV2G and Enhanced Liver Fibrosis Score in Patients with Non-Alcoholic Fatty Liver Disease from Tertiary Care Centres.” Alimentary Pharmacology & Therapeutics 50, no. 11–12 (December 2019): 1214–22. https://doi.org/10.1111/apt.15529.
Kaboré, Elisé G., Charles Guenancia, Ines Vaz-Luis, Antonio Di Meglio, Barbara Pistilli, Charles Coutant, Paul Cottu, et al. “Association of Body Mass Index and Cardiotoxicity Related to Anthracyclines and Trastuzumab in Early Breast Cancer: French CANTO Cohort Study.” PLoS Medicine 16, no. 12 (December 2019): e1002989. https://doi.org/10.1371/journal.pmed.1002989.
Heidegger, Isabel, Igor Tsaur, Hendrik Borgmann, Christian Surcel, Alexander Kretschmer, Romain Mathieu, Pieter De Visschere, et al. “Hereditary Prostate Cancer - Primetime for Genetic Testing?” Cancer Treatment Reviews 81 (December 2019): 101927. https://doi.org/10.1016/j.ctrv.2019.101927.
Steinmeyer, Zara, Stéphane Gérard, Thomas Filleron, Stéphanie Lozano, Delphine Brechemier, Gabor Abellan Van Kan, Loic Mourey, et al. “Low Lean Mass and Chemotherapy Toxicity Risk in the Elderly: The Fraction Study Protocol.” BMC Cancer 19, no. 1 (November 27, 2019): 1153. https://doi.org/10.1186/s12885-019-6377-7.
Flot, Claire, Isabelle Oliver, Philippe Caron, Frédérique Savagner, Maithé Tauber, Ségolène Claeyssens, and Thomas Edouard. “Acquired von Willebrand’s Syndrome Caused by Primary Hypothyroidism in a 5-Year-Old Girl.” Journal of Pediatric Endocrinology & Metabolism: JPEM 32, no. 11 (November 26, 2019): 1295–98. https://doi.org/10.1515/jpem-2019-0082.
Vasseur, Antoine, Luc Cabel, Olivier Tredan, Marion Chevrier, Coraline Dubot, Véronique Lorgis, William Jacot, et al. “Prognostic Value of CEC Count in HER2-Negative Metastatic Breast Cancer Patients Treated with Bevacizumab and Chemotherapy: A Prospective Validation Study (UCBG COMET).” Angiogenesis, November 26, 2019. https://doi.org/10.1007/s10456-019-09697-7.
Orion, C., M. Dinulescu, S. Dalac-Rat, D. Giacchero, T. Jouary, C. Lebbé, M.-T. Leccia, et al. “[Stage III melanoma: Sentinel node biopsy, completion lymph node dissection and prospects of adjuvant therapy. A French national survey on current and envisaged practices].” Annales De Dermatologie Et De Venereologie, November 21, 2019. https://doi.org/10.1016/j.annder.2019.08.018.
Piau, Antoine, Gilles Bourgade, Caroline Berbon, Fati Nourhashemi, Camille Louit, and Laurent Balardy. “Access to Individualized Oncology Care for Older Patients in Complex Healthcare Networks: The Skilled Nurse Option.” Journal of Geriatric Oncology, November 15, 2019. https://doi.org/10.1016/j.jgo.2019.10.014.
Balaguer, Mathieu, Jérôme Farinas, Pascale Fichaux-Bourin, Michèle Puech, Julien Pinquier, and Virginie Woisard. “Validation of the French Versions of the Speech Handicap Index and the Phonation Handicap Index in Patients Treated for Cancer of the Oral Cavity or Oropharynx.” Folia Phoniatrica et Logopaedica: Official Organ of the International Association of Logopedics and Phoniatrics (IALP), November 15, 2019, 1–14. https://doi.org/10.1159/000503448.
Montfort, Anne, Carine Dufau, Céline Colacios, Nathalie Andrieu-Abadie, Thierry Levade, Thomas Filleron, Jean-Pierre Delord, Maha Ayyoub, Nicolas Meyer, and Bruno Ségui. “Anti-TNF, a Magic Bullet in Cancer Immunotherapy?” Journal for Immunotherapy of Cancer 7, no. 1 (November 14, 2019): 303. https://doi.org/10.1186/s40425-019-0802-y.
Marion, Olivier, Sebastien Lhomme, Manon Nayrac, Martine Dubois, Mélanie Pucelle, Mary Requena, Marion Migueres, et al. “Hepatitis E Virus Replication in Human Intestinal Cells.” Gut, November 14, 2019. https://doi.org/10.1136/gutjnl-2019-319004.
Attal, Michel, Paul G. Richardson, S. Vincent Rajkumar, Jesus San-Miguel, Meral Beksac, Ivan Spicka, Xavier Leleu, et al. “Isatuximab plus Pomalidomide and Low-Dose Dexamethasone versus Pomalidomide and Low-Dose Dexamethasone in Patients with Relapsed and Refractory Multiple Myeloma (ICARIA-MM): A Randomised, Multicentre, Open-Label, Phase 3 Study.” Lancet (London, England), November 14, 2019. https://doi.org/10.1016/S0140-6736(19)32556-5.
Le, Dung T., Tae Won Kim, Eric Van Cutsem, Ravit Geva, Dirk Jäger, Hiroki Hara, Matthew Burge, et al. “Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164.” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, November 14, 2019, JCO1902107. https://doi.org/10.1200/JCO.19.02107.
Sarkozy, Clementine, Stacy Hung, Katsuyoshi Takata, Elizabeth Chavez, Tomohiro Aoki, Gerben Duns, Graham W. Slack, et al. “Mutational Landscape of Grey Zone Lymphoma.” Blood 134, no. Supplement_1 (November 13, 2019): 21. https://doi.org/10.1182/blood-2019-127375.
Legros, Laurence, Franck E. Nicolini, Gabriel Etienne, Philippe Rousselot, Delphine Rea, Stephane Giraudier, Agnès Guerci, et al. “The TKI-Free Duration after a First Discontinuation Attempt That Failed in CP CML Patients Is a Predictive Factor of TKI-Free Remission after a Second Attempt.” Blood 134, no. Supplement_1 (November 13, 2019): 28. https://doi.org/10.1182/blood-2019-123719.

LES MEMBRES DE L’ÉQUIPE

Jean-Marc Alliot
Chercheur invité / visiting researcher

LES PARTENAIRES & FINANCIERS

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches contre le Cancer de Toulouse (Oncopole)

Toulouse - FR

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