Rapid detection of a cancer biomarker by a microfluidic chip
Researchers at LAAS-CNRS, in collaboration with the Toulouse Cancer Research Centre, have shown how the μLAS microfluidic chip technology can concentrate and measure cancer biomarker microRNAs in less than a minute.
MicroRNAs (miRs) are short fragments of RNA that play a role in gene expression. Their concentration is strongly altered in cancer patients, which is why miRs are a target of choice for diagnosis and monitoring of patients, provided that a detection and measurement method is sufficiently sensitive and rapid to be used clinically. Researchers at LAAS-CNRS, in collaboration with the Toulouse Cancer Research Centre, have made an important breakthrough in this direction, by achieving the detection of miR-21 in less than one minute using a microfluidic chip. These results are published in the journal Biosensors and Bioelectronics.
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Micro-RNA 21 detection with a limit of 2 pM in 1 min using a size-accordable concentration module operated by electrohydrodynamic actuation
I. Tijunelyte, R. Malbec, B. Chami, J. Cacheux, C. Dez, T. Leichlé, P. Cordelier, A. Bancaud.
Biosensors and Bioelectronics Volume 178, 15 April 2021
DOI: 10.1016/j.bios.2021.112992
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