PIPgen: a new Innovative Training Network to put PI3K/PTEN related diseases under the spotlight

PIPgen brings together 9 leading European basic and clinical institutions and 3 private companies experts in the PI3K/PTEN field, to train 15 researchers at the Phd level in a wide range of scientific and complementary competences. The PI3 Kinase, regulated by the PTEN protein, is central in a metabolic pathway controlling cell growth, survival, and proliferation. Both proteins are found mutated in many human cancers. The main goal of this H2020 funded project is to change the European biomedical landscape in PI3K/PTEN-related diseases.

PIPgen stems from the emerging links between monogenic rare diseases and cancer. There are more than 7000 rare diseases, affecting approximately 30 million European Union citizens. Eighty percent of these have genetic origin and are often chronic or life-threatening. Interestingly, many of the genetic alterations present in rare diseases are also implicated in cancer, a fundamental biological problem of Epidemic Proportions (>14 million new cases/year worldwide).

Genetic alterations in the phosphoinositide 3-kinase (PI3K)/PTEN pathway are common events in both monogenic rare diseases and cancer, presenting a truly unique paradigm of which PIPgen will take advantage. The European project PIPgen, seeks to impact in the assessment and treatment of PI3K monogenic rare diseases and cancer through the knowledge generated in basic bioscience.

CRCT partner : Julie Guillermet-Guibert

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Previous European funding Phd – Deciphering PI3K Biology in Health and Disease

Start date: 01 November 2015
End date: 31 October 2019

Current European Funding

The fellowships are funded as part of the Marie Skłodowska-Curie Actions (MSCA) Innovative Training Networks under the European Commission’s Horizon 2020 programme.  MARIE CURIE GRANT AGREEMENT NUMBER: 955534.

Start date: 01 July 2021
End date: 30 June 2025

This research programme is part of the European Horizon 2020 Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) call for proposals: https://www.horizon2020.gouv.fr/cid144802/appel-2020-innovative-training-networks-itn.html

Partenaire CRCT (co-coordinateur) : Julie Guillermet-Guibert

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Date de début : 01 novembre 2015
date de fin : 31 octobre 2019

Ce programme de recherche entre dans le cadre de l’appel d’offre européen Horizon 2020 Marie Skłodowska-Curie Innovative Training Networks (ITN-ETN) : https://www.horizon2020.gouv.fr/cid144802/appel-2020-innovative-training-networks-itn.html