Overexpression of the oncogenic long non-coding RNA LONA in acute myeloid leukaemia and changes in its cellular localisation by the NPM1c+ mutant protein.
Long non-coding RNA
Acute myeloid leukaemia
NPM1
Contact : Marina Bousquet – t R’N Blood – RNA biology in haematological tumours.
In this study, we describe the oncogenic role of a novel long non-coding RNA (lncRNA) named LONA (LncRNA Overexpressed in NPM1 mutated Acute myeloid leukemia) overexpressed in acute myeloid leukemia (AML) patients carrying the NPM1 nucleophosmin mutation. The presence of the NPM1 mutant induces a shift in cellular localisation from the cytoplasm to the nucleus of the LONA lncRNA, thus affecting its cellular functions. Loss- and gain-of-function strategies have shown that LONA exerts opposite effects on myeloid differentiation depending on whether it is nuclear or cytoplasmic by regulating the expression of crucial genes such as THBS1, ASB2 or MAFB. In vivo, overexpression of LONA reduces the survival of transplanted mice, whereas its inactivation sensitises them to cytarabine treatment.
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Discover the published article
Leukemia. 2021 Jun 15:1-15.
A novel leukemic route of mutant NPM1 through nuclear import of the overexpressed long noncoding RNA LONA.
Gourvest M, De Clara E, Wu HC, Touriol C, Meggetto F, De Thé H, Pyronnet S, Brousset P, Bousquet M.
Collaborations and acknowledgements
Toulouse Cancer Research Center (Oncopole)
Toulouse – FR
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