team

mARC POIROT & SANDRINE SILVENTE-POIROT

 

INOV :

Cholesterol Metabolism and
Therapeutic Innovations

Team labelled Ligue contre le Cancer

THE SPECIFICITIES

OF OUR RESEARCH AXIS

We explore the role of cholesterol metabolism in the control of tumor progression and in the resistance to therapies in several cancers (breast, skin, thyroid, leukemia). We are studying the biological properties and biosynthetic pathways of two metabolites that we have discovered: dendrogenin A (DDA) and oncosterone (OCDO) which are respectively tumor suppressor and tumor promoter metabolites. The ultimate goal of these studies is to develop new drug candidates and theranostic tools for new targeted and personalized cancer therapies. They will also define the role of the sterol component of the diet on the development of certain cancers.

Our Webinars

 LIPID MAPS Webinar – Dr Marc Poirot – 28.03.2023: Recent discoveries on the cholesterol metabolic pathway: the 5,6-epoxycholesterol branch, dendrogenins and oncosterone

 International society for extracellular vesicles: 31.05.2023: Immunogenic EVs in cancer

La recherche s’intéresse à mon assiette : 20.09.2023 : Relations entre alimentation et maladies dégénératives : le cas du cholesterol

réseau Nutrition Alimentation, activité physique, recherche (NACRe): WebiNACRe n°11, 4rth july 2024: Cholesterol et cancer

oncometabolism

cholesterol

oxysterol

oncosterone

secretory vesicles

exosomes

dendrogenin

nuclear receptors

enzymes

metabolic imaging

research projects

THE TEAM’S
FOCUS

Discover

The Enzyme Cholesterol-5,6-Epoxide Hydrolase: A Key Regulator in Various Diseases

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Focus research 2022 INOV team

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Dr Marc Poirot is laureate of the Schroepfer Prize 2023

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Recent discoveries on the cholesterol metabolic pathway

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A cholesterol derivative to produce reprogrammed tumour exosomes that activate the immune system against tumours

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Understand

Fascination with new therapeutic approaches

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Pink October: Breast cancer awareness month

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On the occasion of the World Cancer Day, digital round table “Toulouse: innovation in oncology (in french)

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Participate

TOW2025 J-30 Earlybird registration

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Philippe de Medina joins the editorial board of The Journal of Steroid Biochemistry and Molecular Biology

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12th Summer School on Medicines

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SCIENTIFIC PRODUCTIONS

PUBLICATIONS 2024
Khallouki, Farid, Wafa Zennouhi, Lhoussain Hajji, Mohamed Bourhia, Laila Benbacer, Bachir El Bouhali, Leila Rezig, Marc Poirot, and Gérard Lizard. “Current Advances in Phytosterol Free Forms and Esters: Classification, Biosynthesis, Chemistry, and Detection.” Steroids 212 (December 2024): 109520. https://doi.org/10.1016/j.steroids.2024.109520.
Bydlowski, Sergio P., and Marc Poirot. “Editorial: Lipids, Lipid Oxidation, and Cancer: From Biology to Therapeutics.” Frontiers in Oncology 14 (April 19, 2024): 1414992. https://doi.org/10.3389/fonc.2024.1414992.
Poirot, Marc, Luigi Iuliano, William J. Griffiths, and Gerard Lizard. “11th ENOR Meeting: Oxysterols in Human Health and Diseases.” The Journal of Steroid Biochemistry and Molecular Biology 239 (February 27, 2024): 106495. https://doi.org/10.1016/j.jsbmb.2024.106495.
deMedina, Philippe, Silia Ayadi, Khadijetou Diallo, Julio Buñay, Laly Pucheu, Regis Soulès, Michel Record, et al. “The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases.” Advances in Experimental Medicine and Biology 1440 (2024): 149–61. https://doi.org/10.1007/978-3-031-43883-7_8.
PUBLICATIONS 2023
Dieudonné, Arnaud, Clément Bailly, Florent Cachin, Agathe Edet-Sanson, Françoise Kraeber-Bodéré, Sébastien Hapdey, Charles Merlin, et al. “Dosimetry for Targeted Radionuclide Therapy in Routine Clinical Practice: Experts Advice vs. Clinical Evidence.” European Journal of Nuclear Medicine and Molecular Imaging, December 19, 2023. https://doi.org/10.1007/s00259-023-06568-8.
Boucher, Aymeric, Julia Delabie, Charlotte Lussey-Lepoutre, Magalie Haissaguerre, Eric Ouvrard, Vija Lavinia, Maëlle Le Bras, et al. “Performance of [18F]Fluorocholine PET/CT in MEN1-Related Primary Hyperparathyroidism before Initial Surgery or for Persistent/Recurrent Disease.” European Journal of Nuclear Medicine and Molecular Imaging, December 7, 2023. https://doi.org/10.1007/s00259-023-06537-1.
Ayadi, Silia, Silvia Friedrichs, Regis Soulès, Laly Pucheu, Dieter Lütjohann, Sandrine Silvente-Poirot, Marc Poirot, and Philippe de Medina. “27-Hydroxylation of Oncosterone by CYP27A1 Switches Its Activity from pro-Tumor to Anti-Tumor.” Journal of Lipid Research 64, no. 12 (December 2023): 100479. https://doi.org/10.1016/j.jlr.2023.100479.
deMédina, Philippe, Silia Ayadi, Régis Soulès, Bruno Payre, Sandrine Rup-Jacques, Sandrine Silvente-Poirot, Mohammad Samadi, and Marc Poirot. “Chemical Synthesis and Biochemical Properties of Cholestane-5α,6β-Diol-3-Sulfonate: A Non-Hydrolysable Analogue of Cholestane-5α,6β-Diol-3β-Sulfate.” The Journal of Steroid Biochemistry and Molecular Biology 234 (November 2023): 106396. https://doi.org/10.1016/j.jsbmb.2023.106396.
Taprogge, Jan, Alex Vergara-Gil, Francesca Leek, Carla Abreu, Lenka Vávrová, Lily Carnegie-Peake, Sarah Schumann, et al. “Normal Organ Dosimetry for Thyroid Cancer Patients Treated with Radioiodine as Part of the Multi-Centre Multi-National Horizon 2020 MEDIRAD Project.” European Journal of Nuclear Medicine and Molecular Imaging 50, no. 11 (September 2023): 3225–34. https://doi.org/10.1007/s00259-023-06295-0.
Ben Hassen, Céline, Caroline Goupille, Claire Vigor, Thierry Durand, Françoise Guéraud, Sandrine Silvente-Poirot, Marc Poirot, and Philippe G. Frank. “Is Cholesterol a Risk Factor for Breast Cancer Incidence and Outcome?” The Journal of Steroid Biochemistry and Molecular Biology 232 (September 2023): 106346. https://doi.org/10.1016/j.jsbmb.2023.106346.
Khallouki, Farid, Lhoussain Hajji, Somayya Saber, Toufik Bouddine, Mouad Edderkaoui, Mohammed Bourhia, Nora Mir, et al. “An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management.” Journal of Personalized Medicine 13, no. 5 (April 28, 2023): 754. https://doi.org/10.3390/jpm13050754.
Weyl, Ariane, Charlotte Chollet, Erwan Gabiache, Valérie Cancès-Lauwers, Franklin Gallo, Alejandra Martinez, Frederic Courbon, et al. “PET-MRI for Evaluation of Response to Radiochemotherapy in Patients with Locally Advanced Cervical Cancer.” International Journal of Gynecologic Cancer 33, no. 5 (2023): 676–82. https://doi.org/10.1136/ijgc-2022-003958.
PUBLICATIONS 2022
Maronnier, Quentin, Frédéric Courbon, and Olivier Caselles. “Evaluation of a Method Based on Synthetic Data Inserted into Raw Data Prior to Reconstruction for the Assessment of PET Scanners.” EJNMMI Physics 9, no. 1 (October 1, 2022): 68. https://doi.org/10.1186/s40658-022-00496-6.
Clement, Dominique, Shaunak Navalkissoor, Rajaventhan Srirajaskanthan, Frédéric Courbon, Lawrence Dierickx, Amy Eccles, Valerie Lewington, et al. “Efficacy and Safety of 177Lu‑DOTATATE in Patients with Advanced Pancreatic Neuroendocrine Tumours: Data from the NETTER-R International, Retrospective Study.” European Journal of Nuclear Medicine and Molecular Imaging 49, no. 10 (August 2022): 3529–37. https://doi.org/10.1007/s00259-022-05771-3.
Lizard, Gérard, Marc Poirot, and Luigi Iuliano. “Celebrating the 10th Anniversary of the Creation of the European Network for Oxysterol Research (ENOR).” The Journal of Steroid Biochemistry and Molecular Biology 221 (July 2022): 106114. https://doi.org/10.1016/j.jsbmb.2022.106114.
deMedina, Philippe, Sandrine Silvente-Poirot, and Marc Poirot. “Oxysterols Are Potential Physiological Regulators of Ageing.” Ageing Research Reviews 77 (May 2022): 101615. https://doi.org/10.1016/j.arr.2022.101615.
Record, Michel, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, et al. “Targeting the Liver X Receptor with Dendrogenin A Differentiates Tumour Cells to Secrete Immunogenic Exosome-Enriched Vesicles.” Journal of Extracellular Vesicles 11, no. 4 (April 2022): e12211. https://doi.org/10.1002/jev2.12211.
Sabatier, Renaud, Cécile Vicier, Séverine Garnier, Arnaud Guille, Nadine Carbuccia, Nicolas Isambert, Florence Dalenc, et al. “Circulating Tumor DNA Predicts Efficacy of a Dual AKT/P70S6K Inhibitor (LY2780301) plus Paclitaxel in Metastatic Breast Cancer: Plasma Analysis of the TAKTIC Phase IB/II Study.” Molecular Oncology, February 5, 2022. https://doi.org/10.1002/1878-0261.13188.
Websdale, Alex, Yi Kiew, Philip Chalmers, Xinyu Chen, Giorgia Cioccoloni, Thomas A. Hughes, Xinyu Luo, et al. “Pharmacologic and Genetic Inhibition of Cholesterol Esterification Enzymes Reduces Tumour Burden: A Systematic Review and Meta-Analysis of Preclinical Models.” Biochemical Pharmacology 196 (February 2022): 114731. https://doi.org/10.1016/j.bcp.2021.114731.
Poirot, Marc. “Sterol Metabolism and Cancer.” Biochemical Pharmacology 196 (February 2022): 114843. https://doi.org/10.1016/j.bcp.2021.114843.
Khallouki, Farid, Somayya Saber, Toufik Bouddine, Lhoussain Hajji, Bachir Elbouhali, Sandrine Silvente-Poirot, and Marc Poirot. “In Vitro and In Vivo Oxidation and Cleavage Products of Tocols: From Chemical Tuners to ‘VitaminEome’ Therapeutics. A Narrative Review.” Food Bioscience 49 (2022): 101839. https://doi.org/10.1016/j.fbio.2022.101839.
Lambert, Marie, Lawrence Dierickx, Séverine Brillouet, Frédéric Courbon, and Etienne Chatelut. “Comparison of Two Types of Amino Acid Solutions on 177Lu-Dotatate Pharmacokinetics and Pharmacodynamics in Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumors.” Current Radiopharmaceuticals 15, no. 2 (2022): 164–72. https://doi.org/10.2174/1874471015666211228123525.
PUBLICATIONS 2021
Lizard, Gérard, Marc Poirot, and Luigi Iuliano. “European Network for Oxysterol Research (ENOR): 10 Th Anniversary.” The Journal of Steroid Biochemistry and Molecular Biology 214 (November 2021): 105996. https://doi.org/10.1016/j.jsbmb.2021.105996.
deMedina, Philippe, Khadijetou Diallo, Emilie Huc-Claustre, Mehdi Attia, Régis Soulès, Sandrine Silvente-Poirot, and Marc Poirot. “The 5,6-Epoxycholesterol Metabolic Pathway in Breast Cancer: Emergence of New Pharmacological Targets.” British Journal of Pharmacology 178, no. 16 (August 2021): 3248–60. https://doi.org/10.1111/bph.15205.
Montfort, Anne, Florie Bertrand, Julia Rochotte, Julia Gilhodes, Thomas Filleron, Jean Milhès, Carine Dufau, et al. “Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.” Cancer Immunology Research 9, no. 5 (May 2021): 568–82. https://doi.org/10.1158/2326-6066.CIR-20-0342.
Klionsky, Daniel J., Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, et al. “Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition)1.” Autophagy 17, no. 1 (January 2021): 1–382. https://doi.org/10.1080/15548627.2020.1797280.
PUBLICATIONS 2020
Mouchel, Pierre-Luc, Nizar Serhan, Rémy Betous, Thomas Farge, Estelle Saland, Philippe De Medina, Jean-Sébastien Hoffmann, et al. “Dendrogenin A Enhances Anti-Leukemic Effect of Anthracycline in Acute Myeloid Leukemia.” Cancers 12, no. 10 (October 12, 2020): 2933. https://doi.org/10.3390/cancers12102933.
Serhan, Nizar, Pierre-Luc Mouchel, Philippe de Medina, Gregory Segala, Aurélie Mougel, Estelle Saland, Arnaud Rives, et al. “Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo.” Cancers 12, no. 7 (June 29, 2020): 1725. https://doi.org/10.3390/cancers12071725.
Alsuliman, Tamim, Caroline Baylet, Audrey Casabona, Marie-Pierre Dann, Natacha De Bentzmann, Marie-Laure Fontoura, Carole Genty, et al. “Vie sexuelle et affective après allogreffe de cellules souches hématopoïétiques : recommandations et livret patient de la SFGM-TC (Société francophone de greffe de moelle et de thérapie cellulaire).” Bulletin du Cancer, 2020, S0007455120302976. https://doi.org/10.1016/j.bulcan.2020.05.012.
Rodriguez-Estrada, M.T., V. Cardenia, M. Poirot, L. Iuliano, and G. Lizard. “Oxysterols and Sterols: From Lipidomics to Food Sciences.” The Journal of Steroid Biochemistry and Molecular Biology 196 (2020): 105515. https://doi.org/10.1016/j.jsbmb.2019.105515.
PUBLICATIONS 2019
Soulès, Régis, Fabien Audouard-Combe, Emilie Huc-Claustre, Philippe de Medina, Arnaud Rives, Etienne Chatelut, Florence Dalenc, et al. “A Fast UPLC-HILIC Method for an Accurate Quantification of Dendrogenin A in Human Tissues.” The Journal of Steroid Biochemistry and Molecular Biology 194 (August 12, 2019): 105447. https://doi.org/10.1016/j.jsbmb.2019.105447.
Poirot, Marc, Sandrine Silvente-Poirot, and Cholesterol metabolism and therapeutic innovations. “Oxysterols: An Expanding Family of Structurally Diversified Bioactive Steroids.” The Journal of Steroid Biochemistry and Molecular Biology, July 31, 2019, 105443. https://doi.org/10.1016/j.jsbmb.2019.105443.
Bauriaud-Mallet, Mathilde, Lavinia Vija-Racaru, Séverine Brillouet, Arnaud Mallinger, Philippe de Medina, Arnaud Rives, Bruno Payre, Marc Poirot, Fréderic Courbon, and Sandrine Silvente-Poirot. “The Cholesterol-Derived Metabolite Dendrogenin A Functionally Reprograms Breast Adenocarcinoma and Undifferentiated Thyroid Cancer Cells.” The Journal of Steroid Biochemistry and Molecular Biology 192 (June 3, 2019): 105390. https://doi.org/10.1016/j.jsbmb.2019.105390.
Fouache, Allan, Nada Zabaiou, Cyrille De Joussineau, Laurent Morel, Sandrine Silvente-Poirot, Amira Namsi, Gérard Lizard, et al. “Flavonoids Differentially Modulate Liver X Receptors Activity-Structure-Function Relationship Analysis.” The Journal of Steroid Biochemistry and Molecular Biology 190 (April 5, 2019): 173–82. https://doi.org/10.1016/j.jsbmb.2019.03.028.
Genovese, Salvatore, Francesco Epifano, Philippe de Medina, Nicolas Caron, Arnaud Rives, Marc Poirot, Sandrine Silvente-Poirot, and Serena Fiorito. “Natural and Semisynthetic Oxyprenylated Aromatic Compounds as Stimulators or Inhibitors of Melanogenesis.” Bioorganic Chemistry 87 (March 14, 2019): 181–90. https://doi.org/10.1016/j.bioorg.2019.03.026.
Taddeo, Vito Alessandro, Francesco Epifano, Francesca Preziuso, Serena Fiorito, Nicolas Caron, Arnaud Rives, Philippe de Medina, Marc Poirot, Sandrine Silvente-Poirot, and Salvatore Genovese. “HPLC Analysis and Skin Whitening Effects of Umbelliprenin-Containing Extracts of Anethum Graveolens, Pimpinella Anisum, and Ferulago Campestris.” Molecules (Basel, Switzerland) 24, no. 3 (January 30, 2019). https://doi.org/10.3390/molecules24030501.

TEAM MEMBERS

Lavinia Vija
Clinicien Chercheur / Researcher hospital practitioner
Michel Record
Chercheur statutaire / permanent scientist
Marc Poirot
Chercheur statutaire / permanent scientist
Sandrine Poirot
Chercheur statutaire / permanent scientist
Julio Bunay
Chercheur Post-Doctorant / Post-Doc researcher
Séverine Brillouet
Clinicien Chercheur / Researcher hospital practitioner
Philippe De-Medina
Ingénieur de laboratoire / laboratory engineer
Khadijetou Diallo
Doctorant / PhD student
Laly Pucheu
Technicien de laboratoire / Laboratory Technician

PARTERNSHIPS & FUNDING

Centre de Recherches en Cancérologie de Toulouse

Toulouse Cancer Research Center (Oncopole)

Toulouse - FR

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+33 5 82 74 15 75

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