Équipe
Pierre Cordelier

ImPact :

Innovation thérapeutique dans le cancer du pancréas

Les spécificités

de notre axe de recherche

Le cancer du pancréas, ou adénocarcinome pancréatique, deviendra bientôt la seconde cause de décès par cancer dans le monde, en raison d’un diagnostic tardif et de l’absence de traitements efficaces. Notre effort de recherche est consacré à la mise en place de nouvelles stratégies anticancéreuses afin d’améliorer la prise en charge des patients atteints de ce cancer.

Dans ce contexte, notre objectif de recherche est de mieux comprendre les mécanismes d’oncogenèse et de résistance thérapeutique dans ce cancer. Plus particulièrement, nous étudions le rôle du remodelage et de la réplication du génome dans l’expression génique et la résistance aux agents provoquant des cassures de l’ADN (Projet 1). Nous étudions les protéines et les interactions protéines-protéines impliquées dans l’oncogenèse pancréatique et la résistance au traitement à l’aide d’anticorps intracellulaires (Projet 2). Enfin, nous recherchons les mécanismes responsables de la résistance des cellules cancéreuses aux virus oncolytiques, et étudions l’impact de ces virus sur la réponse immunitaire antitumorale (Projet 3).

Dans son ensemble, ce projet de recherche a pour objectif de traduire nos découvertes de recherche fondamentale en innovations thérapeutiques tangibles pour les patients atteints de cancer du pancréas, selon une approche de médecine de précision.

Cancer du Pancréas

Oncogenèse

Résistance

Thérapies innovantes

Régulation de l’expression génique

Interaction protéine-protéine

Anticorps intracellulaire

Virus oncolytiques

Thérapie génique

Immunothérapie

interdisciplinarité

DES PROJETS
DE RECHERCHE

LES FOCUS
DE L’ÉQUIPE

Découvrir

Rendre les cellules cancéreuses du pancréas plus vulnérables en ciblant un processus lié à la production d’énergie dans les mitochondries, dépendante d’une enzyme appelée cytidine désaminase

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Seconde saison des Apprentis Chercheurs au CRCT

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L’E3 ubiquitine ligase TRIP12 est nécessaire à la plasticité des cellules acineuses pancréatiques et à au développement du cancer du pancréas.

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Un virus oncolytique qui cible spécifiquement les cellules cancéreuses pancréatiques les plus agressives

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La cytidine désaminase protège les cellules cancéreuses des médicaments ciblant l’ADN.

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Comprendre

Septembre en Or, mois international des cancers de l’enfant

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Éradiquer le cancer par thérapie génique : espoir ou utopie ?

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10 ans de recherche contre le Cancer : Toulouse au cœur de la lutte

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La cellule tumorale

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L’immunothérapie en cancérologie

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Participer

TOW2025 J-30 inscription anticipée

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Recherche sur le cancer du pancréas : le projet FRAP sélectionné par l’INCa

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L’équipe ImPact obtient la prestigieuse labellisation de la Fondation ARC pendant 3 ans

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En live

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PRODUCTIONS SCIENTIFIQUES

PUBLICATIONS 2024
Maulat, Charlotte, Cindy Canivet, Bastien Cabarrou, Anne Pradines, Janick Selves, Anne Casanova, Aurélia Doussine, et al. “Prognostic Impact of Circulating Tumor DNA Detection in Portal and Peripheral Blood in Resected Pancreatic Ductal Adenocarcinoma Patients.” Scientific Reports 14, no. 1 (November 8, 2024): 27296. https://doi.org/10.1038/s41598-024-76903-y.
Frances, Audrey, Audrey Lumeau, Nicolas Bery, Marion Gayral, Lucille Stuani, Marie Sorbara, Estelle Saland, et al. “Cytidine Deaminase-Dependent Mitochondrial Biogenesis as a Potential Vulnerability in Pancreatic Cancer Cells.” Communications Biology 7, no. 1 (August 30, 2024): 1065. https://doi.org/10.1038/s42003-024-06760-y.
Brunet, Manon, Claire Vargas, Marjorie Fanjul, Damien Varry, Naïma Hanoun, Dorian Larrieu, Laetitia Pieruccioni, et al. “The E3 Ubiquitin Ligase TRIP12 Is Required for Pancreatic Acinar Cell Plasticity and Pancreatic Carcinogenesis.” The Journal of Pathology, June 25, 2024. https://doi.org/10.1002/path.6298.
Cornebois, Anaïs, Marie Sorbara, Margot Cristol, Emmanuelle Vigne, Pierre Cordelier, Klervi Desrumeaux, and Nicolas Bery. “Discovery of SOCS7 as a Versatile E3 Ligase for Protein-Based Degraders.” IScience 27, no. 5 (May 17, 2024): 109802. https://doi.org/10.1016/j.isci.2024.109802.
Lumeau, Audrey, Nicolas Bery, Audrey Francès, Marion Gayral, Guillaume Labrousse, Cyril Ribeyre, Charlene Lopez, et al. “Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs.” Cancer Research 84, no. 7 (April 1, 2024): 1013–28. https://doi.org/10.1158/0008-5472.CAN-22-3219.
Vienne, Margaux, Charlène Lopez, Hubert Lulka, Adèle Nevot, Guillaume Labrousse, Nelson Dusetti, Louis Buscail, and Pierre Cordelier. “Minute Virus of Mice Shows Oncolytic Activity against Pancreatic Cancer Cells Exhibiting a Mesenchymal Phenotype.” Molecular Therapy. Oncology 32, no. 1 (March 21, 2024): 200780. https://doi.org/10.1016/j.omton.2024.200780.
Nicolle, Rémy, Cindy Canivet, Laurent Palazzo, Bertrand Napoléon, Mira Ayadi, Camille Pignolet, Jérôme Cros, et al. “Predictive Genomic and Transcriptomic Analysis on Endoscopic Ultrasound-Guided Fine Needle Aspiration Materials from Primary Pancreatic Adenocarcinoma: A Prospective Multicentre Study.” EBioMedicine 109 (2024): 105373. https://doi.org/10.1016/j.ebiom.2024.105373.
PUBLICATIONS 2023
Keyan, Kripa S., Safa Salim, Swetha Gowda, Doua Abdelrahman, Syeda Sakina Amir, Zeyaul Islam, Claire Vargas, et al. “Control of TGFβ Signalling by Ubiquitination Independent Function of E3 Ubiquitin Ligase TRIP12.” Cell Death & Disease 14, no. 10 (October 20, 2023): 692. https://doi.org/10.1038/s41419-023-06215-y.
Barbey, Odile, Hubert Lulka, Naima Hanoun, Hafid Belhadj-Tahar, Fabienne Vernejoul, Gilles Cambois, Michèle Tiraby, Louis Buscail, Fabian Gross, and Pierre Cordelier. “Preclinical Development of Non-Viral Gene Therapy for Patients with Advanced Pancreatic Cancer.” Molecular Therapy. Methods & Clinical Development 29 (June 8, 2023): 162–72. https://doi.org/10.1016/j.omtm.2023.03.005.
Le Cosquer, Guillaume, Charlotte Maulat, Barbara Bournet, Pierre Cordelier, Etienne Buscail, and Louis Buscail. “Pancreatic Cancer in Chronic Pancreatitis: Pathogenesis and Diagnostic Approach.” Cancers 15, no. 3 (January 26, 2023): 761. https://doi.org/10.3390/cancers15030761.
PUBLICATIONS 2022
Quillien, Lorraine, Louis Buscail, and Pierre Cordelier. “Pancreatic Cancer Cell and Gene Biotherapies; Past, Present and Future.” Human Gene Therapy, December 31, 2022. https://doi.org/10.1089/hum.2022.210.
Chaves-Almagro, Carline, Johanna Auriau, Alizée Dortignac, Pascal Clerc, Hubert Lulka, Simon Deleruyelle, Fabrice Projetti, et al. “Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development.” International Journal of Molecular Sciences 23, no. 18 (September 13, 2022): 10600. https://doi.org/10.3390/ijms231810600.
Keller, Laura, Claudine Tardy, Laetitia Ligat, Soazig Le Pennec, Nicolas Bery, Faten Koraïchi, Patrick Chinestra, et al. “Tripartite Split-GFP Assay to Identify Selective Intracellular Nanobody That Suppresses GTPase RHOA Subfamily Downstream Signaling.” Frontiers in Immunology 13 (August 18, 2022): 980539. https://doi.org/10.3389/fimmu.2022.980539.
Sorbara, Marie, Pierre Cordelier, and Nicolas Bery. “Antibody-Based Approaches to Target Pancreatic Tumours.” Antibodies 11, no. 3 (July 12, 2022): 47. https://doi.org/10.3390/antib11030047.
Cordelier, Pierre, Manon Costa, and Jérôme Fehrenbach. “Slow-Fast Model and Therapy Optimization for Oncolytic Treatment of Tumors.” Bulletin of Mathematical Biology 84, no. 6 (May 10, 2022): 64. https://doi.org/10.1007/s11538-022-01025-3.
Bery, Nicolas, and Terry H. Rabbitts. “A Cell-Based Screening Method Using an Intracellular Antibody for Discovering Small Molecules Targeting Hard-to-Drug Proteins.” Bio-Protocol 12, no. 4 (February 20, 2022): e4324. https://doi.org/10.21769/BioProtoc.4324.
Buscail, Louis. “[Pancreatic tumors: a hierarchical diagnostic and therapeutic].” La Revue Du Praticien 72, no. 2 (February 2022): 210.
Rouanet, Marie, Naima Hanoun, Hubert Lulka, Cindy Ferreira, Pierre Garcin, Martin Sramek, Godefroy Jacquemin, et al. “The Antitumoral Activity of TLR7 Ligands Is Corrupted by the Microenvironment of Pancreatic Tumors.” Molecular Therapy, January 2022, S1525001622000181. https://doi.org/10.1016/j.ymthe.2022.01.018.
PUBLICATIONS 2021
Marinho, Anthony, Nicolas Zalay, Léonor Chaltiel, Sylvain Kirzin, Antoine Philis, Jannick Selves, Nicolas Carrère, Etienne Buscail, and Laurent Ghouti. “Oncologic and Functional Outcomes of Pelvic Perineal Reconstruction by Perineal Colostomy and Malone Procedure After Abdominoperineal Resection.” Diseases of the Colon and Rectum 64, no. 12 (December 1, 2021): 1501–10. https://doi.org/10.1097/DCR.0000000000001941.
Sorbara, Marie, and Nicolas Bery. “Targeting Small GTPases and Their Downstream Pathways with Intracellular Macromolecule Binders to Define Alternative Therapeutic Strategies in Cancer.” Biochemical Society Transactions 49, no. 5 (November 1, 2021): 2021–35. https://doi.org/10.1042/BST20201059.
Thibault, Benoit, Fernanda Ramos-Delgado, Elvire Pons-Tostivint, Nicole Therville, Celia Cintas, Silvia Arcucci, Stephanie Cassant-Sourdy, et al. “Pancreatic Cancer Intrinsic PI3Kα Activity Accelerates Metastasis and Rewires Macrophage Component.” EMBO Molecular Medicine 13, no. 7 (July 7, 2021): e13502. https://doi.org/10.15252/emmm.202013502.
Montfort, Anne, Florie Bertrand, Julia Rochotte, Julia Gilhodes, Thomas Filleron, Jean Milhès, Carine Dufau, et al. “Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.” Cancer Immunology Research 9, no. 5 (May 2021): 568–82. https://doi.org/10.1158/2326-6066.CIR-20-0342.
Tijunelyte, Inga, Rémi Malbec, Bayan Chami, Jean Cacheux, Christophe Dez, Thierry Leichlé, Pierre Cordelier, and Aurélien Bancaud. “Micro-RNA 21 Detection with a Limit of 2 PM in 1 Min Using a Size-Accordable Concentration Module Operated by Electrohydrodynamic Actuation.” Biosensors & Bioelectronics 178 (April 15, 2021): 112992. https://doi.org/10.1016/j.bios.2021.112992.
Quillien, Lorraine, Sokunthea Top, Sandrine Kappler-Gratias, Agathe Redouté, Nelson Dusetti, Charlotte Quentin-Froignant, Hubert Lulka, et al. “A Novel Imaging Approach for Single-Cell Real-Time Analysis of Oncolytic Virus Replication and Efficacy in Cancer Cells.” Human Gene Therapy 32, no. 3–4 (February 2021): 166–77. https://doi.org/10.1089/hum.2020.294.
PUBLICATIONS 2020
Frere, Corinne, Benjamin Crichi, Barbara Bournet, Cindy Canivet, Nassim Ait Abdallah, Louis Buscail, and Dominique Farge. “Primary Thromboprophylaxis in Ambulatory Pancreatic Cancer Patients Receiving Chemotherapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Cancers 12, no. 8 (July 24, 2020): 2028. https://doi.org/10.3390/cancers12082028.
Amintas, Samuel, Aurélie Bedel, François Moreau-Gaudry, Julian Boutin, Louis Buscail, Jean-Philippe Merlio, Véronique Vendrely, Sandrine Dabernat, and Etienne Buscail. “Circulating Tumor Cell Clusters: United We Stand Divided We Fall.” International Journal of Molecular Sciences 21, no. 7 (April 10, 2020): E2653. https://doi.org/10.3390/ijms21072653.
Maulat, Charlotte, Cindy Canivet, Célia Touraine, Sophie Gourgou, Bertrand Napoleon, Laurent Palazzo, Nicolas Flori, et al. “A New Score to Predict the Resectability of Pancreatic Adenocarcinoma: The BACAP Score.” Cancers 12, no. 4 (March 25, 2020): 783. https://doi.org/10.3390/cancers12040783.
Frances, Audrey, and Pierre Cordelier. “The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?” Molecular Therapy: The Journal of the American Society of Gene Therapy, February 5, 2020. https://doi.org/10.1016/j.ymthe.2019.11.026.
Buscail, Louis, Barbara Bournet, and Pierre Cordelier. “Role of Oncogenic KRAS in the Diagnosis, Prognosis and Treatment of Pancreatic Cancer.” Nature Reviews. Gastroenterology & Hepatology, January 31, 2020. https://doi.org/10.1038/s41575-019-0245-4.
Larrieu, D., M. Brunet, C. Vargas, N. Hanoun, L. Ligat, L. Dagnon, H. Lulka, et al. “The E3 Ubiquitin Ligase TRIP12 Participates in Cell Cycle Progression and Chromosome Stability.” Scientific Reports 10, no. 1 (January 21, 2020): 789. https://doi.org/10.1038/s41598-020-57762-9.
Lumeau, Audrey, and Pierre Cordelier. “One Two Punch: Combination Chemotherapy Knocks Out Pancreatic Cancer.” Molecular Therapy 28, no. 8 (2020): 1751–52. https://doi.org/10.1016/j.ymthe.2020.07.014.
Nicolle, Rémy, Yuna Blum, Pauline Duconseil, Charles Vanbrugghe, Nicolas Brandone, Flora Poizat, Julie Roques, et al. “Establishment of a Pancreatic Adenocarcinoma Molecular Gradient (PAMG) That Predicts the Clinical Outcome of Pancreatic Cancer.” EBioMedicine 57 (2020): 102858. https://doi.org/10.1016/j.ebiom.2020.102858.
Frere, Corinne, Barbara Bournet, Sophie Gourgou, Julien Fraisse, Cindy Canivet, Jean M. Connors, Louis Buscail, et al. “Incidence of Venous Thromboembolism in Patients With Newly Diagnosed Pancreatic Cancer and Factors Associated With Outcomes.” Gastroenterology 158, no. 5 (2020): 1346-1358.e4. https://doi.org/10.1053/j.gastro.2019.12.009.
Amintas, Samuel, Véronique Vendrely, Charles Dupin, Louis Buscail, Christophe Laurent, Barbara Bournet, Jean-Philippe Merlio, et al. “Next-Generation Cancer Biomarkers: Extracellular Vesicle DNA as a Circulating Surrogate of Tumor DNA.” Frontiers in Cell and Developmental Biology 8 (2020): 622048. https://doi.org/10.3389/fcell.2020.622048.
PUBLICATIONS 2019
Diaz-Riascos, Zamira Vanessa, Mireia M. Ginesta, Joan Fabregat, Teresa Serrano, Juli Busquets, Louis Buscail, Pierre Cordelier, and Gabriel Capellá. “Expression and Role of MicroRNAs from the MiR-200 Family in the Tumor Formation and Metastatic Propensity of Pancreatic Cancer.” Molecular Therapy. Nucleic Acids 17 (June 29, 2019): 491–503. https://doi.org/10.1016/j.omtn.2019.06.015.
Buscail, Etienne, Charlotte Maulat, Fabrice Muscari, Laurence Chiche, Pierre Cordelier, Sandrine Dabernat, Catherine Alix-Panabières, and Louis Buscail. “Liquid Biopsy Approach for Pancreatic Ductal Adenocarcinoma.” Cancers 11, no. 6 (June 19, 2019). https://doi.org/10.3390/cancers11060852.
Dromain, Clarisse, Marianne E. Pavel, Philippe Ruszniewski, Alison Langley, Christine Massien, Eric Baudin, Martyn E. Caplin, and CLARINET Study Group. “Tumor Growth Rate as a Metric of Progression, Response, and Prognosis in Pancreatic and Intestinal Neuroendocrine Tumors.” BMC Cancer 19, no. 1 (January 14, 2019): 66. https://doi.org/10.1186/s12885-018-5257-x.
Cacheux, Jean, Aurélien Bancaud, Thierry Leichlé, and Pierre Cordelier. “Technological Challenges and Future Issues for the Detection of Circulating MicroRNAs in Patients With Cancer.” Frontiers in Chemistry 7 (2019): 815. https://doi.org/10.3389/fchem.2019.00815.

LES MEMBRES DE L’ÉQUIPE

Léa Badin
Ingénieur de laboratoire / laboratory engineer
Noémie Delenclos
Master / Master student
Margot Cristol
Master / Master student
Laura Jouvin
Doctorant / PhD student
Nina Suarez
Ingénieur de laboratoire / laboratory engineer
Jean Cacheux
Chercheur Post-Doctorant / Post-Doc researcher
Alban Ricard
Doctorant / PhD student
Damien Varry
Doctorant / PhD student
Barbara Bournet
Hospitalo-Universitaire / University teacher hospital practitioner
Nicolas Carrère
Hospitalo-Universitaire / University teacher hospital practitioner
Charlotte Maulat
Doctorant / PhD student
Louis Buscail
Hospitalo-Universitaire / University teacher hospital practitioner
Fabrice Muscari
Enseignant chercheur / University researcher
Jérôme Torrisani
Chercheur statutaire / permanent scientist
Nikolaos Kontopoulos
Doctorant / PhD student
Pierre Cordelier
Chercheur statutaire / permanent scientist
Agathe Redouté
Doctorant / PhD student
Marie Sorbara
Doctorant / PhD student
Naïma Hanoun-Ziane
Ingénieur de laboratoire / laboratory engineer
Nicolas Béry
Chercheur statutaire / permanent scientist

LES PARTENAIRES & FINANCIERS

Centre de Recherches en Cancérologie de Toulouse

Centre de Recherches contre le Cancer de Toulouse (Oncopole)

Toulouse - FR

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+33 5 82 74 15 75

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