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CRCT Conferences

Identity theft by natural killers : NK cells steal PD-1 from tumor cells via trogocytosis

Lecture by Dr Michele Ardolino, Ottawa Hospital, Research Institute

Videoconference Teams given on Friday 09 September in the framework of the CRCT Scientific Animation Committee

NK cells are important mediators of anti-tumor immunity and, as such, tumors often adopt strategies to evade NK cell recognition or killing. Whether PD-1, an inhibitory receptor commonly known to potently suppress T cells, can inhibit NK cell functions remain unclear. In this seminar, I will discuss our data showing that PD-1 acts as a checkpoint for NK cells and our surprising discovery that NK cells, rather than endogenously express PD-1, acquire it from cancer cells via trogocytosis.

Videoconference