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Identity theft by natural killers : NK cells steal PD-1 from tumor cells via trogocytosis
Lecture by Dr Michele Ardolino, Ottawa Hospital, Research Institute
Videoconference Teams given on Friday 09 September in the framework of the CRCT Scientific Animation Committee
NK cells are important mediators of anti-tumor immunity and, as such, tumors often adopt strategies to evade NK cell recognition or killing. Whether PD-1, an inhibitory receptor commonly known to potently suppress T cells, can inhibit NK cell functions remain unclear. In this seminar, I will discuss our data showing that PD-1 acts as a checkpoint for NK cells and our surprising discovery that NK cells, rather than endogenously express PD-1, acquire it from cancer cells via trogocytosis.
DATE
09 september 2022
LOCATION
Conference 53 minutes et 41 seconds
Visioconference Teams
INFORMATIONS
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Videoconference
Michele Ardolino
Toulouse Cancer Research Center (Oncopole)
Toulouse – FR
CRCT-Oncopole Follow 1,433 1,279
Compte officiel du Centre de Recherches en Cancérologie de Toulouse
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➡️https://www.crct-inserm.fr/en/targeting-the-energy-production-process-in-pancreatic-cancer-cells-which-relies-on-an-enzyme-called-cytidine-deaminase-could-make-these-cells-more-vulnerable/
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