Focus research 2022 NetB(IO)² team
Studying 3D DNA in the nucleus
The NetB(IO)² team has been studying the organization of DNA in 3D for many years, using analogies that represent DNA regions as nodes in a network that are connected if they are close together, just as a social network has links between people who know each other. This network is very important in the case of cancer, as cancer cells sometimes show alterations, not in the genes, but in the switches.
In a recent paper, the team used the network of connections between genes and switches, which can be viewed on the GARDEN-NET web, to identify a new biomarker in large T-cell lymphocytic leukemia. Another application of this network analogy enabled the team to discover how DNA replication – the process that makes one copy of DNA before the cell divides – is organized three-dimensionally, potentially exploiting the same organization used for gene regulation.
To find out more about the IUCT-Oncopole and CRCT-Oncopole research focuses, please click here
Toulouse Cancer Research Center (Oncopole)
Toulouse - FR
CRCT-Oncopole Follow 1,433 1,279
Compte officiel du Centre de Recherches en Cancérologie de Toulouse
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🇬🇧Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cells. ImPact team @CordelierPierre article from @crctoncopole published in @CommsBio
➡️https://www.crct-inserm.fr/en/targeting-the-energy-production-process-in-pancreatic-cancer-cells-which-relies-on-an-enzyme-called-cytidine-deaminase-could-make-these-cells-more-vulnerable/
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