Encouraging phase 1 results of hypofractionated stereotactic re-irradiation in combination with Durvalumab in recurrent Glioblastoma.

Hypofractionated stereotactic radiotherapy (hFSRT) is a salvage option for recurrent glioblastoma (GB) that can synergise with anti-PDL1 therapy. This phase I study evaluated the safety and recommended phase II dose of anti-PDL1 durvalumab combined with hypofractionated stereotactic radiotherapy in patients with recurrent GB.

Six patients were included. One dose-limiting toxicity, Durvalumab-related grade 3 vestibular neuritis, was reported. The median progression-free interval (PFI) and overall survival (OS) were 2.3 and 16.7 months, respectively. A multimodal deep learning analysis including MRI, cytokines and lymphocyte/neutrophil ratio was used to isolate patients with pseudoprogression, the longest PFI and those with the longest OS.

The combination of hFSRT and Durvalumab in recurrent WBC was well tolerated in this phase I study. These encouraging results have led to a randomised phase II trial  that has just been completed and on which these first data will be validated.

Collaborations et acknowledgments

We thank Astra Zeneca for funding the clinical trial and the ARC foundation for grants supporting the SI2GMA project of the SIGN’IT program. We also thank all patients and their caregivers who participated in this study.