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Targeting the energy production process in pancreatic cancer cells, which relies on an enzyme called cytidine deaminase, could make these cells more vulnerablen ligase TRIP12 is required for pancreatic acinar cell plasticity and the development of pancreatic cancer.
The E3 ubiquitin ligase TRIP12 is required for pancreatic acinar cell plasticity and the development of pancreatic cancer.
Prevention of resistances to targeted therapies in lung cancer with a new therapeutic combination.
Intraepithelial tumor-infiltrating lymphocytes shape loco-regional PET/CT spread of locally advanced cervical cancer.
The regulation of mRNA translation by RNA G-quadruplex structures contributes to cancer progression and resistance to treatment
New publication on Autophagy
TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
Human genetic defects of sphingolipid synthesis
An oncolytic virus with strong appetence for the most aggressive type of pancreatic cancer cells
Cytidine deaminase confers resistance to DNA-damaging drugs
Study of the contribution of tumour lipids to the metastatic progression of cutaneous melanoma
The Enzyme Cholesterol-5,6-Epoxide Hydrolase: A Key Regulator in Various Diseases
Roxana Khazen, winner of the ARC Foundation’s call for “passerelle” projects
Identification and characterisation of the cells responsible for the initiation of B-lineage leukaemias
Kartezio: a fully transparent AI-based approach to biomedical image analysis
A new MRI technique can locate foci of aggressive tumour cells and could improve the treatment of glioblastoma
Surface-guided radiotherapy overview: Technical aspects and clinical applications.
Autophagy contributes to resistance to ruxolitinib in myeloproliferative neoplasms
CD36 drives metastasis and relapse in acute myeloid leukemia
A computational model of the formation of cells limiting the effect of promising cancer therapies
Cancer under pressure: which signals are activated?
Cancer: a key mechanism for improving immunotherapies identified by a Toulouse team
The power of the intestine against metastases
The level of von Willebrand factor is a pronostic marker in patients with metastatic melanoma treated by immune checkpoint inhibitors
Encouraging phase 1 results of hypofractionated stereotactic re-irradiation in combination with Durvalumab in recurrent Glioblastoma.
Dr Marc Poirot is laureate of the Schroepfer Prize 2023
Fabienne Meggetto awarded by the Amgen France Fund
A new target to fight certain aggressive leukaemias
Recent discoveries on the cholesterol metabolic pathway
Preclinical development of non-viral gene therapy for patients with advanced pancreatic cancer
Acquired genetic abnormalities predict outcome in patients with GATA2 deficiency
Top 5 CRCT publications for the year 2022
Single-cell spatial explorer a software to to analyse the cells characteristics in relation with their position in any kind of biological tissue
How to target PI3Ks 3 classes in cancer?
Lessons from the melanoma ecosystem
Pancreatic cancer cell and gene biotherapies; past, present and future
Resisting T cell attack: tumor-cell-intrinsic defense and reparation mechanisms.
Towards a new approach to immunotherapy in the treatment of skin cancers
Fighting bronchial cancers
The Roland Garigou Foundation for Culture & Health awards several prizes and grants to the CRCT in 2022
Welcome to the Brain Galaxy
Deregulation of protein synthesis in pancreatic cancer
Integrative single-cell multi-omics analyses to understand Leukemia resistance.
Jean-Emmanuel Sarry receives the Guy Lazorthes Prize of the Academy of Sciences 2022
Identity theft by natural killers : NK cells steal PD-1 from tumor cells via trogocytosis
Loélia Babin Young Talent Award 2022 of the L’Oréal Foundation for Women in Science
Heterogeneity in long-term outcomes for R-ISS stage II in newly diagnosed multiple myeloma patients
A cholesterol derivative to produce reprogrammed tumour exosomes that activate the immune system against tumours
Analysis of circular RNAs by the Oxford Nanopore long-read sequencing platform
Obesity and melanoma: a new link
Web database about RNA structures called RNA G-Quarduplexes and their interaction with RNA binding proteins
Design of an intracellularly acting antibody blocking the RHOA family of proteins to study a cellular process involved in carcinogenesis.
Diversity in rRNA 2’Ome profiles in cancer and impact on translational regulation
Dendrogenin A reprograms tumor cells to secrete exosomes which activate the immune system against cancer
Cholesterol is involved in ageing processes
NeoVirTech SAS opens a new laboratory at the Cancerology Research Center of Toulouse (CRCT)
Presentation of the CREFRE UMS006 Inserm phenotyping service
Impact of co-administration of two amino acid solutions on the elimination and adverse effects of 177Lu-Dotatate
TLR7 agonists have dual effect on pancreatic tumors that jeopardize their use in clinics
An intermediate level of genetic instability of the tumor is more favorable to an increase in tumor aggressiveness than a low or very high level
The Roland Garigou Foundation for Culture & Health awards several prizes and grants to the CRCT
Role of genetic mutations in trabectedin liver toxicity.
Identification of therapeutic targets and repositioning of drugs against COVID-19 through the analysis of interaction networks between proteins, drugs, pathologies and symptoms
Protocol for selecting antibodies that degrade their antigen in cells.
Normalization of protein secretions in the tumor microenvironment blocks metastasis in pancreatic cancer
The CRCT and the IUCT-o will participate in the INTREPIDS project
Real-time analysis of replication and activity of oncolytic viruses in pancreatic cancer
Rapid and sensitive detection of biomarkers of interest in cancerology
The value of screening for DPD activity in all patients treated with fluoropyrimidines.
A new immunotherapy strategy for melanoma patients.
The cell signalling enzymes PI3Kalpha and PI3Kβ play major roles in the body.
The PACMINE project is selected for the Toulouse Cancer Health Foundation’s call for funds
Rapid detection of a cancer biomarker by a microfluidic chip
Reprogramming a family of lipids to increase the effectiveness of melanoma immunotherapy.
Study of the Interplay effect in Radiotherapy using Monte-Carlo methods.
PI3K proteins sense mechanical forces in tumours.
Première saison des Apprentis Chercheurs au CRCT
Overexpression of the oncogenic long non-coding RNA LONA in acute myeloid leukaemia and changes in its cellular localisation by the NPM1c+ mutant protein.
GAMMORA: a tool to automatically prepare radiotherapy simulations
CRCT Laureate Wins Laurette Fugain Award 2021
Targeted therapies straight to the point or how to counter the defence of cancer cells in response to these therapies?
Laura Poillet-Perez Young Talent Award 2021 of the L’Oréal Foundation for Women in Science
Targeting a family of proteins important for cancer development using intracellular macromolecules
Myeloid leukaemia: understanding treatment resistance to move towards personalised medicine
Role of autophagy in response to targeted therapy in ALK+ lymphoma
From circular RNA to circular RNA derived from chromosomal translocations in hematological malignancies
In search of the cells that cause pediatric leukemia.
The rapid progression and poor prognosis of pancreatic cancer: a therapeutic lead.
Toulouse Cancer Research Center (Oncopole)
Toulouse - FR
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🇬🇧Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cells. ImPact team @CordelierPierre article from @crctoncopole published in @CommsBio
➡️https://www.crct-inserm.fr/en/targeting-the-energy-production-process-in-pancreatic-cancer-cells-which-relies-on-an-enzyme-called-cytidine-deaminase-could-make-these-cells-more-vulnerable/
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