Dr Don Marc Franchini

Characterization and therapeutic targeting of a new immunoregulatory mechanism

Following our recent discovery of a dynamic regulation of the expression of immune checkpoint genes in human T cells, this line of research aims at characterizing this molecular mechanism and targeting it therapeutically. The objective aim at identifying and characterizing the ribonucleoprotein complexes that carry the mRNAs encoding immune checkpoints. These complexes are studied in humans, in the physiological context of normal blood lymphocytes and in the pathological context of lymphoma. In particular, we are developing new molecules specifically targeting these mechanisms and evaluating their therapeutic potential.

Parternships and funding:

Fondation ARC; Toulouse Tech Transfer