TOULOUSE CANCER RESEARCH
CENTER
Basic research at the heart of Oncopole
On a daily basis we are working to find the solutions of tomorrow
At the heart of the Toulouse Oncopole, the CRCT, with all its partners (institutional, academic, clinical, industrial, charitable…), stimulates innovation in terms of research and teaching in the fight against cancer.
The CRCT leads an integrated approach between research, care and teaching, in a transversal and multidisciplinary logic.
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Understanding research at CRCT
Gene dysfunction is a hallmark of cancer. At the CRCT, we aim to discover how this process occurs. Several molecular oncogenic mechanisms are studied by our teams, including cancer cell signaling, genetic instability, gene expression, interconnection between cancer cells and the tumor microenvironment, bioenergetics…
We have set up research axes to explore the molecular complexity of cancer cells and tumor diversity, and we combine the strengths of our research teams to study the different aspects of cell transformation: our goal is to put together all the pieces of the “puzzle” that is cancer, in order to understand what initiates it and makes it progress.
4 fundamental research axis
ONCOGENIC PATHWAYS
OF CANCER: FROM MODELLING TO TARGETED THERAPY
The objective is to federate researchers, clinicians, engineers, technicians and students of the CRCT in order to share a multidisciplinary expertise with the common goal of understanding and targeting the autonomous and non-autonomous mechanisms of cancer oncogenic pathways.
RNA &
CANCER
CRCT researchers are exploring the mechanisms of deregulation of RNAs, key players in the control of gene expression, and their role in altering the cellular landscape that can lead to cancer initiation, progression, invasion and metastasis.
TUMOUR MICROENVIRONMENT AND METABOLISM
The objective of this axis is to understand and identify targets in both tumour cells and stroma, the co-targeting of which could sensitise tumours to therapies and/or abrogate their metastatic potential.
ONCO-IMMUNOLOGY
The aim of this axis is to promote collaboration between several teams by studying the cancer/immunity confrontation through different but complementary approaches.
LABEX TOUCAN
Labex TOUCAN is a research programme financed by the Agence Nationale de la Recherche (ANR) under the Programme des Investissements d’Avenir (PIA).
Toulouse Cancer Research Center (Oncopole)
Toulouse - FR
CRCT-Oncopole Follow 1,433 1,279
Compte officiel du Centre de Recherches en Cancérologie de Toulouse
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🇬🇧Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cells. ImPact team @CordelierPierre article from @crctoncopole published in @CommsBio
➡️https://www.crct-inserm.fr/en/targeting-the-energy-production-process-in-pancreatic-cancer-cells-which-relies-on-an-enzyme-called-cytidine-deaminase-could-make-these-cells-more-vulnerable/
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