Colorectal tumors are heterogeneous and hierarchical. Tumor growth relies on the proliferation of cancer stem cells, which constantly produce non-proliferative differentiated cells that eventually die. Despite this hierarchy, treatments targeting cancer stem cells often fail at eradicating the tumor, because the remaining cancer cells dedifferentiate to replenish the stem cell pool. It is thus crucial […]

Lien vers la visioconférence   Abstract : In myeloid leukaemias, the rapid clonal expansion of leukemic cells in the bone marrow leads to alterations of microenvironment properties, and reduction of the overall availability for each cell type in the constrained space of the medullar niche. In addition, bone marrow fibrosis that often occurs in myeloid […]

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Important : reportée de 11h40 à 12h10 Pour suivre la conférence à distance, cliquez ici. Abstract : Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably with the identification of K27M mutations in histone H3. However, the synergistic oncogenic mechanisms […]

Pour suivre la conférence à distance, cliquez ici. Abstract: Most cancer somatic alterations occur in the noncoding portion of the human genome, which contains important cis-regulatory regions acting as genetic switches to ensure gene expression occurs at correct times and intensities in correct tissues. However, the identification of critical noncoding cancer driver events has been […]

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Pour suivre la conférence à distance, cliquez ici. Abstract: The concept of patient trajectory is important in understanding a disease as a dynamic process that evolves over time. Evaluating patient trajectories typically involves longitudinal (diachronic) datasets, which are still relatively scarce and expensive. Drawing from the concepts of pseudotime and the ergodic principle in single-cell […]