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Colorectal tumors are heterogeneous and hierarchical. Tumor growth relies on the proliferation of cancer stem cells, which constantly produce non-proliferative differentiated cells that eventually die. Despite this hierarchy, treatments targeting cancer stem cells often fail at eradicating the tumor, because the remaining cancer cells dedifferentiate to replenish the stem cell pool. It is thus crucial […]

Lien vers la visioconférence   Abstract : In myeloid leukaemias, the rapid clonal expansion of leukemic cells in the bone marrow leads to alterations of microenvironment properties, and reduction of the overall availability for each cell type in the constrained space of the medullar niche. In addition, bone marrow fibrosis that often occurs in myeloid […]