team
Ludovic MARTINET & Hervé avet-LOISEAU

GENIM :

Genomic and Immunology of myeloma

The Toulouse Cancer Laboratory of Excellence is a project that aims to understand the mechanisms of resistance and relapse in cancer.

the specifities

of our research axis

Multiple Myeloma

Genomic alterations

Clonal selection

Resistance

Immunity

Cytotoxic Lymphocyte

Immune escape

Immunotherapy

research projects

THE TEAM’S
FOCUS

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Focus research 2022 GENIM team

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Cancer: a key mechanism for improving immunotherapies identified by a Toulouse team

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Heterogeneity in long-term outcomes for R-ISS stage II in newly diagnosed multiple myeloma patients

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Very soon more news from this team to follow….

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Understand

On the occasion of the World Cancer Day, digital round table “Toulouse: innovation in oncology (in french)

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Participate

TOW2025 J-30 Earlybird registration

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12th Summer School on Medicines

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SCIENTIFIC PRODUCTIONS

PUBLICATIONS 2024
Morandi, Elena, Véronique Adoue, Isabelle Bernard, Ekaterina Friebel, Nicolas Nunez, Yann Aubert, Frederick Masson, et al. “Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions.” Neurology(R) Neuroimmunology & Neuroinflammation 11, no. 6 (November 2024): e200306. https://doi.org/10.1212/NXI.0000000000200306.
Eckmann, Jan, Tanja Fauti, Marlene Biehl, Aintzane Zabaleta, Laura Blanco, Iva Lelios, Stefan Gottwald, et al. “Forimtamig, a Novel GPRC5D-Targeting T-Cell Bispecific Antibody with a 2+1 Format, for the Treatment of Multiple Myeloma.” Blood, October 30, 2024, blood.2024025987. https://doi.org/10.1182/blood.2024025987.
Blanquart, Eve, Rüçhan Ekren, Bineta Rigaud, Marie Veronique Joubert, Virginie Baylot, Hélène Daunes, Marine Cuisinier, et al. “NK Cells with Adhesion Defects and Reduced Cytotoxic Functions Are Associated with a Poor Prognosis in Multiple Myeloma.” Blood, June 14, 2024, blood.2023023529. https://doi.org/10.1182/blood.2023023529.
Schavgoulidze, Anaïs, Jill Corre, Mehmet K. Samur, Celine Mazzotti, Luka Pavageau, Aurore Perrot, Titouan Cazaubiel, et al. “RAS/RAFlandscape in Monoclonal Plasma Cell Conditions.” Blood, April 21, 2024, blood.2023022295. https://doi.org/10.1182/blood.2023022295.
Frenzel, Laurent, Olivier Decaux, Margaret Macro, Karim Belhadj-Merzoug, Salomon Manier, Cyrille Touzeau, Xavier Leleu, et al. “Venous Thromboembolism Prophylaxis and Multiple Myeloma Patients in Real-Life: Results of a Large Survey and Clinical Guidance Recommendations from the IFM Group.” Thrombosis Research 233 (January 2024): 153–64. https://doi.org/10.1016/j.thromres.2023.11.021.
PUBLICATIONS 2023
Lucca, Liliana E. “Multiple Myeloma Treatment: One Bridge Closer.” Blood 142, no. 21 (November 23, 2023): 1763–64. https://doi.org/10.1182/blood.2023022470.
Aubry, Arthur, Joel D. Pearson, Jason Charish, Tao Yu, Jeremy M. Sivak, Dimitris P. Xirodimas, Hervé Avet-Loiseau, Jill Corre, Philippe P. Monnier, and Rod Bremner. “Deneddylation of Ribosomal Proteins Promotes Synergy between MLN4924 and Chemotherapy to Elicit Complete Therapeutic Responses.” Cell Reports 42, no. 8 (August 29, 2023): 112925. https://doi.org/10.1016/j.celrep.2023.112925.
Pichler, Andrea C., Nadège Carrié, Marine Cuisinier, Samira Ghazali, Alison Voisin, Pierre-Paul Axisa, Marie Tosolini, et al. “TCR-Independent CD137 (4-1BB) Signaling Promotes CD8+-Exhausted T Cell Proliferation and Terminal Differentiation.” Immunity, June 27, 2023, S1074-7613(23)00264-9. https://doi.org/10.1016/j.immuni.2023.06.007.
Schavgoulidze, Anais, Valerie Lauwers-Cances, Aurore Perrot, Titouan Cazaubiel, Marie-Lorraine Chretien, Philippe Moreau, Thierry Facon, et al. “Heterogeneity in Long-Term Outcomes for Patients with Revised International Staging System Stage II, Newly Diagnosed Multiple Myeloma.” Haematologica 108, no. 5 (May 1, 2023): 1374–84. https://doi.org/10.3324/haematol.2021.280566.
Lannes, Romain, Mehmet Samur, Aurore Perrot, Celine Mazzotti, Marion Divoux, Titouan Cazaubiel, Xavier Leleu, et al. “In Multiple Myeloma, High-Risk Secondary Genetic Events Observed at Relapse Are Present From Diagnosis in Tiny, Undetectable Subclonal Populations.” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 41, no. 9 (March 20, 2023): 1695–1702. https://doi.org/10.1200/JCO.21.01987.
PUBLICATIONS 2022
Termini, Rosalinda, David Žihala, Evangelos Terpos, Albert Perez-Montaña, Tomáš Jelínek, Marc Raab, Niels Weinhold, et al. “Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 28, no. 21 (November 1, 2022): 4771–81. https://doi.org/10.1158/1078-0432.CCR-22-1594.
Martin, Tom, Paul G. Richardson, Thierry Facon, Philippe Moreau, Aurore Perrot, Ivan Spicka, Kamlesh Bisht, et al. “Primary Outcomes by 1q21+ Status for Isatuximab-Treated Patients with Relapsed/Refractory Multiple Myeloma: Subgroup Analyses from ICARIA-MM and IKEMA.” Haematologica 107, no. 10 (October 1, 2022): 2485–91. https://doi.org/10.3324/haematol.2022.280660.
Dahmani, Cylia, Eulalie Corre, Sarah Dandou, Alain Mangé, Ovidiu Radulescu, Peter J. Coopman, Pierre Cuq, and Romain M. Larive. “[Resistance to BRAF inhibitors: A lesson from clinical observations].” Medecine Sciences: M/S 38, no. 6–7 (July 2022): 570–78. https://doi.org/10.1051/medsci/2022083.
Kassem, Sahar, Béré K. Diallo, Nizar El-Murr, Nadège Carrié, Alexandre Tang, Alain Fournier, Hélène Bonnevaux, et al. “SAR442085, a Novel Anti-CD38 Antibody with Enhanced Antitumor Activity against Multiple Myeloma.” Blood 139, no. 8 (February 24, 2022): 1160–76. https://doi.org/10.1182/blood.2021012448.
Cazaubiel, Titouan, Xavier Leleu, Aurore Perrot, Salomon Manier, Laure Buisson, Sabrina Mahéo, Laura Do Souto Ferreira, et al. “Primary Plasma Cell Leukemia Displaying t(11;14) Have Specific Genomic, Transcriptional and Clinical Feature.” Blood, February 16, 2022, blood.2021014968. https://doi.org/10.1182/blood.2021014968.
Marchais, Antonin, Maria Eugenia Marques Da Costa, Bastien Job, Rachid Abbas, Damien Drubay, Sophie Piperno-Neumann, Olivia Fromigué, et al. “Immune Infiltrate and Tumor Microenvironment Transcriptional Programs Stratify Pediatric Osteosarcoma into Prognostic Groups at Diagnosis.” Cancer Research, January 25, 2022, canres.CAN-20-4189-A.2020. https://doi.org/10.1158/0008-5472.CAN-20-4189.
Dummer, Reinhard, Georgina V. Long, Caroline Robert, Hussein A. Tawbi, Keith T. Flaherty, Paolo A. Ascierto, Paul D. Nathan, et al. “Randomized Phase III Trial Evaluating Spartalizumab Plus Dabrafenib and Trametinib for BRAF V600-Mutant Unresectable or Metastatic Melanoma.” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, January 14, 2022, JCO2101601. https://doi.org/10.1200/JCO.21.01601.
Grand, Anaïs, Jean-Baptiste Desbouges, Coralie Guillemot, Coline Spinau, and Florent Puisset. “Still Some Constraints Before Generalization of Remote Clinical Trial Monitoring: A Pharmacist’s Point of View of the Lessons From the COVID-19 Pandemic.” JCO Oncology Practice, January 6, 2022, OP2100749. https://doi.org/10.1200/OP.21.00749.
Largeaud, Laetitia, Sarah Bertoli, Emilie Bérard, Suzanne Tavitian, Muriel Picard, Stéphanie Dufrechou, Naïs Prade, et al. “Genomic Landscape of Hyperleukocytic Acute Myeloid Leukemia.” Blood Cancer Journal 12, no. 1 (January 5, 2022): 4. https://doi.org/10.1038/s41408-021-00601-5.
Grenier, Adrien, Laury Poulain, Johanna Mondesir, Arnaud Jacquel, Claudie Bosc, Lucille Stuani, Sarah Mouche, et al. “AMPK-PERK Axis Represses Oxidative Metabolism and Enhances Apoptotic Priming of Mitochondria in Acute Myeloid Leukemia.” Cell Reports 38, no. 1 (January 4, 2022): 110197. https://doi.org/10.1016/j.celrep.2021.110197.
Rossi, Cédric, Marie Tosolini, Pauline Gravelle, Sarah Pericart, Salim Kanoun, Solene Evrard, Julia Gilhodes, et al. “Baseline SUVmax Is Related to Tumor Cell Proliferation and Patient Outcome in Follicular Lymphoma.” Haematologica 107, no. 1 (January 1, 2022): 221–30. https://doi.org/10.3324/haematol.2020.263194.
Daix, Manon, Martina Aida Angeles, Hélène Leray, Kelig Vergriete, Alejandra Martinez, and Gwenael Ferron. “Anterior Pelvic Exenteration and Laterally Extended Pelvic Resection: A Step by Step Procedure.” International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society 32, no. 1 (January 2022): 107–8. https://doi.org/10.1136/ijgc-2021-003047.
Tauziède-Espariat, Arnault, Philipp Sievers, Frédérique Larousserie, Joseph Benzakoun, Delphine Guillemot, Gaëlle Pierron, Mathilde Duchesne, et al. “An Integrative Histopathological and Epigenetic Characterization of Primary Intracranial Mesenchymal Tumors, FET:CREB-Fused Broadening the Spectrum of Tumor Entities in Comparison with Their Soft Tissue Counterparts.” Brain Pathology (Zurich, Switzerland) 32, no. 1 (January 2022): e13010. https://doi.org/10.1111/bpa.13010.
PUBLICATIONS 2021
Corre, Jill, Aurore Perrot, Cyrille Hulin, Denis Caillot, Anne-Marie Stoppa, Thierry Facon, Xavier Leleu, et al. “Improved Survival in Multiple Myeloma during the 2005-2009 and 2010-2014 Periods.” Leukemia 35, no. 12 (December 2021): 3600–3603. https://doi.org/10.1038/s41375-021-01250-0.
Perrot, Aurore. “How I Treat Frontline Transplant-Eligible Multiple Myeloma.” Blood, November 17, 2021, blood.2020008735. https://doi.org/10.1182/blood.2020008735.
Schjesvold, Fredrik, Sara Bringhen, Paul G Richardson, Aurore Perrot, Xavier Leleu, Philippe Moreau, Meletios A Dimopoulos, et al. “Isatuximab plus Pomalidomide and Dexamethasone in Frail Patients with Relapsed/Refractory Multiple Myeloma: ICARIA-MM Subgroup Analysis.” American Journal of Hematology 96, no. 11 (November 1, 2021): E423–27. https://doi.org/10.1002/ajh.26319.
Facon, Thierry, Shaji K. Kumar, Torben Plesner, Robert Z. Orlowski, Philippe Moreau, Nizar Bahlis, Supratik Basu, et al. “Daratumumab, Lenalidomide, and Dexamethasone versus Lenalidomide and Dexamethasone Alone in Newly Diagnosed Multiple Myeloma (MAIA): Overall Survival Results from a Randomised, Open-Label, Phase 3 Trial.” The Lancet. Oncology 22, no. 11 (November 2021): 1582–96. https://doi.org/10.1016/S1470-2045(21)00466-6.
Mohty, Mohamad, Hervé Avet-Loiseau, and Jean-Luc Harousseau. “Requirements for Operational Cure in Multiple Myeloma.” Blood 138, no. 16 (October 21, 2021): 1406–11. https://doi.org/10.1182/blood.2021012854.
Botta, Cirino, Catarina Da Silva Maia, Juan-José Garcés, Rosalinda Termini, Cristina Perez, Irene Manrique, Leire Burgos, et al. “FlowCT for the Analysis of Large Immunophenotypic Datasets and Biomarker Discovery in Cancer Immunology.” Blood Advances, September 29, 2021, bloodadvances.2021005198. https://doi.org/10.1182/bloodadvances.2021005198.
Caulier, Alexis, Murielle Roussel, Pierre Morel, Naelle Lombion, Benoit Branco, Jean Galtier, Cyrille Hulin, et al. “EPIDEMIOLOGICAL LANDSCAPE OF YOUNG MULTIPLE MYELOMA PATIENTS DIAGNOSED EARLIER THAN 40 YEARS: THE FRENCH EXPERIENCE.” Blood, September 3, 2021, blood.2021011285. https://doi.org/10.1182/blood.2021011285.
Derrien, Jennifer, Catherine Guérin-Charbonnel, Victor Gaborit, Loïc Campion, Magali Devic, Elise Douillard, Nathalie Roi, et al. “The DNA Methylation Landscape of Multiple Myeloma Shows Extensive Inter- and Intrapatient Heterogeneity That Fuels Transcriptomic Variability.” Genome Medicine 13, no. 1 (August 9, 2021): 127. https://doi.org/10.1186/s13073-021-00938-3.
Chalopin, Thomas, Nicolas Vallet, Olivier Theisen, Marlène Ochmann, Mourad Tiab, Pascal Godmer, Carole Barin, et al. “No Survival Improvement in Patients with High-Risk Multiple Myeloma Harbouring Del(17p) and/or t(4;14) over the Two Past Decades.” British Journal of Haematology 194, no. 3 (August 2021): 635–38. https://doi.org/10.1111/bjh.17488.
Anderson, Kenneth C., Daniel Auclair, Stacey J. Adam, Amit Agarwal, Melissa Anderson, Herve Avet-Loiseau, Mark Bustoros, et al. “Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, July 28, 2021, clincanres.1059.2021. https://doi.org/10.1158/1078-0432.CCR-21-1059.
Cavo, Michele, Jesus F. F. San-Miguel, Saad Z. Usmani, Katja C. Weisel, Meletios A. A. Dimopoulos, Hervé Avet-Loiseau, Bruno Paiva, et al. “Prognostic Value of Minimal Residual Disease Negativity in Myeloma: Combined Analysis of POLLUX, CASTOR, ALCYONE, MAIA.” Blood, July 21, 2021, blood.2021011101. https://doi.org/10.1182/blood.2021011101.
San-Miguel, Jesus F., Hervé Avet-Loiseau, Bruno Paiva, Shaji K. Kumar, Meletios A. A. Dimopoulos, Thierry Facon, Maria-Victoria Mateos, et al. “Sustained Minimal Residual Disease Negativity With Daratumumab in Newly Diagnosed Multiple Myeloma: MAIA and ALCYONE.” Blood, July 16, 2021, blood.2020010439. https://doi.org/10.1182/blood.2020010439.
Melaiu, Ombretta, Angelica Macauda, Juan Sainz, Diego Calvetti, Maria Sole Facioni, Giuseppe Maccari, Rob Ter Horst, et al. “Common Gene Variants within 3’-Untranslated Regions as Modulators of Multiple Myeloma Risk and Survival.” International Journal of Cancer 148, no. 8 (April 15, 2021): 1887–94. https://doi.org/10.1002/ijc.33377.
Giaccherini, Matteo, Angelica Macauda, Enrico Orciuolo, Marcin Rymko, Karolina Gruenpeter, Charles Dumontet, Malgorzata Raźny, et al. “Genetically Determined Telomere Length and Multiple Myeloma Risk and Outcome.” Blood Cancer Journal 11, no. 4 (April 14, 2021): 74. https://doi.org/10.1038/s41408-021-00462-y.
Avet-Loiseau, Hervé, Jesus San-Miguel, Tineke Casneuf, Shinsuke Iida, Sagar Lonial, Saad Z. Usmani, Andrew Spencer, et al. “Evaluation of Sustained Minimal Residual Disease Negativity With Daratumumab-Combination Regimens in Relapsed and/or Refractory Multiple Myeloma: Analysis of POLLUX and CASTOR.” Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 39, no. 10 (April 1, 2021): 1139–49. https://doi.org/10.1200/JCO.20.01814.
Schavgoulidze, Anaïs, Titouan Cazaubiel, Aurore Perrot, Hervé Avet-Loiseau, and Jill Corre. “Multiple Myeloma: Heterogeneous in Every Way.” Cancers 13, no. 6 (March 13, 2021). https://doi.org/10.3390/cancers13061285.
Corre, Jill, Aurore Perrot, Denis Caillot, Karim Belhadj, Cyrille Hulin, Xavier Leleu, Mohamad Mohty, et al. “Del(17p) without TP53 Mutation Confers a Poor Prognosis in Intensively Treated Newly Diagnosed Patients with Multiple Myeloma.” Blood 137, no. 9 (March 4, 2021): 1192–95. https://doi.org/10.1182/blood.2020008346.
Casneuf, Tineke, Homer C. Adams, Niels W. C. J. van de Donk, Yann Abraham, Jaime Bald, Greet Vanhoof, Koen Van der Borght, et al. “Deep Immune Profiling of Patients Treated with Lenalidomide and Dexamethasone with or without Daratumumab.” Leukemia 35, no. 2 (February 2021): 573–84. https://doi.org/10.1038/s41375-020-0855-4.
Corre, Jill, Nikhil C. Munshi, and Herve Avet-Loiseau. “Risk Factors in Multiple Myeloma: Is It Time for a Revision?” Blood 137, no. 1 (January 7, 2021): 16–19. https://doi.org/10.1182/blood.2019004309.
Klionsky, Daniel J., Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, et al. “Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4th Edition)1.” Autophagy 17, no. 1 (January 2021): 1–382. https://doi.org/10.1080/15548627.2020.1797280.
Ludwig, Heinz, Mario Boccadoro, Philippe Moreau, Jesus San-Miguel, Michele Cavo, Charlotte Pawlyn, Sonja Zweegman, et al. “Recommendations for Vaccination in Multiple Myeloma: A Consensus of the European Myeloma Network.” Leukemia 35, no. 1 (January 2021): 31–44. https://doi.org/10.1038/s41375-020-01016-0.
PUBLICATIONS 2020
Chari, Ajai, Mehmet Kemal Samur, Joaquin Martinez-Lopez, Gordon Cook, Noa Biran, Kwee Yong, Vania Hungria, et al. “Clinical Features Associated with COVID-19 Outcome in Multiple Myeloma: First Results from the International Myeloma Society Data Set.” Blood 136, no. 26 (December 24, 2020): 3033–40. https://doi.org/10.1182/blood.2020008150.
Munshi, Nikhil C., Herve Avet-Loiseau, Kenneth C. Anderson, Paola Neri, Bruno Paiva, Mehmet Samur, Meletios Dimopoulos, et al. “A Large Meta-Analysis Establishes the Role of MRD Negativity in Long-Term Survival Outcomes in Patients with Multiple Myeloma.” Blood Advances 4, no. 23 (December 8, 2020): 5988–99. https://doi.org/10.1182/bloodadvances.2020002827.
Cazaubiel, Titouan, Olga Mulas, Lydia Montes, Anaïs Schavgoulidze, Hervé Avet-Loiseau, Jill Corre, and Aurore Perrot. “Risk and Response-Adapted Treatment in Multiple Myeloma.” Cancers 12, no. 12 (November 24, 2020). https://doi.org/10.3390/cancers12123497.
Kaufman, Jonathan L., Meletios A. Dimopoulos, Darrell White, Lotfi Benboubker, Gordon Cook, Merav Leiba, James Morton, et al. “Daratumumab, Lenalidomide, and Dexamethasone in Relapsed/Refractory Myeloma: A Cytogenetic Subgroup Analysis of POLLUX.” Blood Cancer Journal 10, no. 11 (November 3, 2020): 111. https://doi.org/10.1038/s41408-020-00375-2.
Weulersse, Marianne, Assia Asrir, Andrea C. Pichler, Lea Lemaitre, Matthias Braun, Nadege Carrie, Marie-Veronique Joubert, et al. “Eomes-Dependent Loss of the Co-Activating Receptor CD226 Restrains CD8(+) T Cell Anti-Tumor Functions and Limits the Efficacy of Cancer Immunotherapy.” Immunity 53, no. 4 (October 13, 2020): 824-839.e10. https://doi.org/10.1016/j.immuni.2020.09.006.
Samur, Mehmet Kemal, Anil Aktas Samur, Mariateresa Fulciniti, Raphael Szalat, Tessa Han, Masood Shammas, Paul Richardson, et al. “Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group.” Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 38, no. 27 (September 20, 2020): 3107–18. https://doi.org/10.1200/JCO.20.00461.
Zajec, Marina, Kristine A. Frerichs, Martijn M. van Duijn, Inger S. Nijhof, Claudia A. M. Stege, Hervé Avet-Loiseau, Theo M. Luider, Yolanda B. de Rijke, Joannes F. M. Jacobs, and Niels W. C. J. van de Donk. “Cerebrospinal Fluid Penetrance of Daratumumab in Leptomeningeal Multiple Myeloma.” HemaSphere 4, no. 4 (August 2020): e413. https://doi.org/10.1097/HS9.0000000000000413.
Nakamura, Kyohei, Mark J. Smyth, and Ludovic Martinet. “Cancer Immunoediting and Immune Dysregulation in Multiple Myeloma.” Blood, July 9, 2020. https://doi.org/10.1182/blood.2020006540.
Di Bacco, Alessandra, Nizar J. Bahlis, Nikhil C. Munshi, Hervé Avet-Loiseau, Tamás Masszi, Luísa Viterbo, Ludek Pour, et al. “C-MYC Expression and Maturity Phenotypes Are Associated with Outcome Benefit from Addition of Ixazomib to Lenalidomide-Dexamethasone in Myeloma.” European Journal of Haematology 105, no. 1 (July 2020): 35–46. https://doi.org/10.1111/ejh.13405.
Mason, Mike J., Carolina Schinke, Christine L. P. Eng, Fadi Towfic, Fred Gruber, Andrew Dervan, Brian S. White, et al. “Multiple Myeloma DREAM Challenge Reveals Epigenetic Regulator PHF19 as Marker of Aggressive Disease.” Leukemia 34, no. 7 (July 2020): 1866–74. https://doi.org/10.1038/s41375-020-0742-z.
Corre, Jill, Lydia Montes, Elodie Martin, Aurore Perrot, Denis Caillot, Xavier Leleu, Karim Belhadj, et al. “Early Relapse after Autologous Transplant for Myeloma Is Associated with Poor Survival Regardless of Cytogenetic Risk.” Haematologica 105, no. 9 (June 5, 2020): e480-483. https://doi.org/10.3324/haematol.2019.236588.
Lemaitre, Léa, Laura Do Souto Ferreira, Marie-Véronique Joubert, Hervé Avet-Loiseau, Ludovic Martinet, Jill Corre, and Bettina Couderc. “Imprinting of Mesenchymal Stromal Cell Transcriptome Persists Even after Treatment in Patients with Multiple Myeloma.” International Journal of Molecular Sciences 21, no. 11 (May 28, 2020): 3854. https://doi.org/10.3390/ijms21113854.
Espagnolle, Nicolas, Benjamin Hebraud, Jean-Gérard Descamps, Mélanie Gadelorge, Marie-Véronique Joubert, Laura Do Souto Ferreira, Murielle Roussel, et al. “Functional Comparison between Healthy and Multiple Myeloma Adipose Stromal Cells.” Stem Cells International 2020 (March 5, 2020): 1–9. https://doi.org/10.1155/2020/4173578.
Avet-Loiseau, Herve, Heinz Ludwig, Ola Landgren, Bruno Paiva, Chris Morris, Hui Yang, Kefei Zhou, Sunhee Ro, and Maria-Victoria Mateos. “Minimal Residual Disease Status as a Surrogate Endpoint for Progression- Free Survival in Newly Diagnosed Multiple Myeloma Studies: A Meta- Analysis.” Clinical Lymphoma, Myeloma & Leukemia 20, no. 1 (January 2020): e30–37. https://doi.org/10.1016/j.clml.2019.09.622.
Rustad, Even H., Venkata Yellapantula, Daniel Leongamornlert, Niccolò Bolli, Guy Ledergor, Ferran Nadeu, Nicos Angelopoulos, et al. “Timing the Initiation of Multiple Myeloma.” Nature Communications 11, no. 1 (2020): 1917. https://doi.org/10.1038/s41467-020-15740-9.
Weisel, Katja, Andrew Spencer, Suzanne Lentzsch, Hervé Avet-Loiseau, Tomer M. Mark, Ivan Spicka, Tamas Masszi, et al. “Daratumumab, Bortezomib, and Dexamethasone in Relapsed or Refractory Multiple Myeloma: Subgroup Analysis of CASTOR Based on Cytogenetic Risk.” Journal of Hematology & Oncology 13, no. 1 (2020): 115. https://doi.org/10.1186/s13045-020-00948-5.
Alberge, Jean-Baptiste, Florence Magrangeas, Mirko Wagner, Soline Denié, Catherine Guérin-Charbonnel, Loïc Campion, Michel Attal, et al. “DNA Hydroxymethylation Is Associated with Disease Severity and Persists at Enhancers of Oncogenic Regions in Multiple Myeloma.” Clinical Epigenetics 12, no. 1 (2020): 163. https://doi.org/10.1186/s13148-020-00953-y.
Soong, David, Jeran Stratford, Herve Avet-Loiseau, Nizar Bahlis, Faith Davies, Angela Dispenzieri, A. Kate Sasser, et al. “CNV Radar: An Improved Method for Somatic Copy Number Alteration Characterization in Oncology.” BMC Bioinformatics 21, no. 1 (2020): 98. https://doi.org/10.1186/s12859-020-3397-x.
Rustad, Even H., Venkata D. Yellapantula, Dominik Glodzik, Kylee H. Maclachlan, Benjamin Diamond, Eileen M. Boyle, Cody Ashby, et al. “Revealing the Impact of Structural Variants in Multiple Myeloma.” Blood Cancer Discovery 1, no. 3 (2020): 258–73. https://doi.org/10.1158/2643-3230.BCD-20-0132.
Braun, Matthias, Amelia Roman Aguilera, Ashmitha Sundarrajan, Dillon Corvino, Kimberley Stannard, Sophie Krumeich, Indrajit Das, et al. “CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells.” Immunity 53, no. 4 (2020): 805-823.e15. https://doi.org/10.1016/j.immuni.2020.09.010.
Terpos, Evangelos, Monika Engelhardt, Gordon Cook, Francesca Gay, Maria-Victoria Mateos, Ioannis Ntanasis-Stathopoulos, Niels W. C. J. van de Donk, et al. “Management of Patients with Multiple Myeloma in the Era of COVID-19 Pandemic: A Consensus Paper from the European Myeloma Network (EMN).” Leukemia 34, no. 8 (2020): 2000–2011. https://doi.org/10.1038/s41375-020-0876-z.
Adamia, Sophia, Ivane Abiatari, Samir B. Amin, Mariateresa Fulciniti, Stephane Minvielle, Cheng Li, Philippe Moreau, Herve Avet-Loiseau, Nikhil C. Munshi, and Kenneth C. Anderson. “The Effects of MicroRNA Deregulation on Pre-RNA Processing Network in Multiple Myeloma.” Leukemia 34, no. 1 (2020): 167–79. https://doi.org/10.1038/s41375-019-0498-5.
PUBLICATIONS 2019
Boyle, Eileen M., Xavier Leleu, Marie-Odile Petillon, Lionel Karlin, Chantal Doyen, Helene Demarquette, Bruno Royer, et al. “Daratumumab and Dexamethasone Is Safe and Effective for Triple Refractory Myeloma Patients: Final Results of the IFM 2014-04 (Etoile Du Nord) Trial.” British Journal of Haematology 187, no. 3 (November 2019): 319–27. https://doi.org/10.1111/bjh.16059.
Pertesi, Maroulio, Maxime Vallee, Xiaomu Wei, Maria V. Revuelta, Perrine Galia, Delphine Demangel, Javier Oliver, et al. “Exome Sequencing Identifies Germline Variants in DIS3 in Familial Multiple Myeloma.” Leukemia 33, no. 9 (September 2019): 2324–30. https://doi.org/10.1038/s41375-019-0452-6.
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team members

David Frieser
Chercheur Post-Doctorant / Post-Doc researcher
Thomas Richarme
Doctorant / PhD student
Amélie Cazes
Technicien de laboratoire / Laboratory Technician
Coralie Franck
Technicien de laboratoire / Laboratory Technician
Samy Kohil
Doctorant / PhD student
Bineta Rigaud
Doctorant / PhD student
Pierre-Paul Axisa
Chercheur Post-Doctorant / Post-Doc researcher
Anaïs Schavgoulidze
Doctorant / PhD student
Luka Pavageau
Ingénieur de laboratoire / laboratory engineer
Celine Mazzotti
Ingénieur de laboratoire / laboratory engineer
Jill Corre
Hospitalo-Universitaire / University teacher hospital practitioner
Laure Buisson
Ingénieur de laboratoire / laboratory engineer
Corentin Pignon
Technicien de laboratoire / Laboratory Technician
Ludovic Martinet
Chercheur statutaire / permanent scientist
Eve Blanquart
Chercheur Post-Doctorant / Post-Doc researcher
Liliana Lucca
Chercheur Post-Doctorant / Post-Doc researcher
Marine Cuisinier
Technicien de laboratoire / Laboratory Technician
Marie-Véronique Joubert
Ingénieur de laboratoire / laboratory engineer
Nadege Constantin Carrié
Ingénieur de laboratoire / laboratory engineer
Rüçhan Ekren
Doctorant / PhD student
12

parternships & funding

Centre de Recherches en Cancérologie de Toulouse

Toulouse Cancer Research Center (Oncopole)

Toulouse - FR

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